eF-site ID 1xd3-A PDB Code 1xd3 Chain A click to enlarge Title Crystal structure of UCHL3-UbVME complex Classification HYDROLASE Compound Ubiquitin Carboxyl-terminal esterase L3 Source Homo sapiens (Human) (UBIQ_HUMAN) Sequence A:  EGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPEL LSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVT SSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKK FLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPS IDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETL LEDAIEVCKKFMERDPDELRFNAIALSAA Description Functional site 1) chain A residue 108 type sequence K description BINDING SITE FOR RESIDUE MG A 2006 source : AC6 2) chain A residue 109 type sequence D description BINDING SITE FOR RESIDUE MG A 2006 source : AC6 3) chain A residue 21 type sequence K description BINDING SITE FOR RESIDUE MG A 2010 source : BC1 4) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE MG A 2010 source : BC1 5) chain A residue 25 type sequence L description BINDING SITE FOR RESIDUE MG A 2010 source : BC1 6) chain A residue 114 type sequence E description BINDING SITE FOR RESIDUE MG A 2010 source : BC1 7) chain A residue 58 type sequence I description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 8) chain A residue 89 type sequence Q description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 9) chain A residue 93 type sequence N description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 10) chain A residue 95 type sequence C description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 11) chain A residue 166 type sequence V description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 12) chain A residue 168 type sequence L description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 13) chain A residue 169 type sequence H description BINDING SITE FOR RESIDUE GVE B 1176 source : BC2 14) chain A residue 89 type catalytic sequence Q description 597 source MCSA : MCSA1 15) chain A residue 95 type catalytic sequence C description 597 source MCSA : MCSA1 16) chain A residue 169 type catalytic sequence H description 597 source MCSA : MCSA1 17) chain A residue 184 type catalytic sequence D description 597 source MCSA : MCSA1 18) chain A residue 95 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:20380862, ECO:0000269|PubMed:9790970 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 169 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 130 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 89-105 type prosite sequence QTISNACGTIGLIHAIA description UCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QtisNACGtigLIHAIA source prosite : PS00140 22) chain A residue 184 type SITE sequence D description Important for enzyme activity => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI3

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