eF-site ID 1xcg-F PDB Code 1xcg Chain F click to enlarge Title Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF Classification SIGNALING PROTEIN ACTIVATOR/SIGNALING PROTEIN Compound Rho guanine nucleotide exchange factor 11 Source Homo sapiens (Human) (RHOA_HUMAN) Sequence F:  AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENY VADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILM CFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLR NDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAK TKDGVREVFEMATRAALQ Description Functional site 1) chain F residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804 source Swiss-Prot : SWS_FT_FI1 2) chain F residue 117 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804 source Swiss-Prot : SWS_FT_FI1 3) chain F residue 30 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P62820 source Swiss-Prot : SWS_FT_FI2 4) chain F residue 59 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P62820 source Swiss-Prot : SWS_FT_FI2 5) chain F residue 160 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P62820 source Swiss-Prot : SWS_FT_FI2 6) chain F residue 34 type MOD_RES sequence Y description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538 source Swiss-Prot : SWS_FT_FI3 7) chain F residue 37 type MOD_RES sequence T description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 source Swiss-Prot : SWS_FT_FI4 8) chain F residue 41 type MOD_RES sequence N description (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215 source Swiss-Prot : SWS_FT_FI5 9) chain F residue 63 type MOD_RES sequence Q description 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0 source Swiss-Prot : SWS_FT_FI6 10) chain F residue 37 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 source Swiss-Prot : SWS_FT_FI8 11) chain F residue 135 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831 source Swiss-Prot : SWS_FT_FI9 12) chain F residue 34 type CARBOHYD sequence Y description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI7

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