eF-site/Summary 1xcg-B

eF-site ID	1xcg-B
PDB Code	1xcg
Chain	B

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Title	Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF
Classification	SIGNALING PROTEIN ACTIVATOR/SIGNALING PROTEIN
Compound	Rho guanine nucleotide exchange factor 11
Source	null (RHOA_HUMAN)

Sequence	B:	AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENY VADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILM CFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLR NDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAK TKDGVREVFEMATRAALQ

Description

Functional site


1)	chain	B
	residue	37
	type	CARBOHYD
	sequence	T
	description	(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269\|PubMed:24905543, ECO:0000269\|PubMed:7775453, ECO:0000269\|PubMed:7777059
	source	Swiss-Prot : SWS_FT_FI8

2)	chain	B
	residue	12
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000269\|PubMed:10748207, ECO:0000269\|PubMed:12777804
	source	Swiss-Prot : SWS_FT_FI1

3)	chain	B
	residue	117
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:10748207, ECO:0000269\|PubMed:12777804
	source	Swiss-Prot : SWS_FT_FI1

4)	chain	B
	residue	34
	type	MOD_RES
	sequence	Y
	description	(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269\|PubMed:19362538
	source	Swiss-Prot : SWS_FT_FI3

5)	chain	B
	residue	37
	type	MOD_RES
	sequence	T
	description	(Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269\|PubMed:19039103
	source	Swiss-Prot : SWS_FT_FI4

6)	chain	B
	residue	41
	type	MOD_RES
	sequence	N
	description	(Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305\|PubMed:1328215
	source	Swiss-Prot : SWS_FT_FI5

7)	chain	B
	residue	63
	type	MOD_RES
	sequence	Q
	description	5-glutamyl serotonin => ECO:0000250\|UniProtKB:Q9QUI0
	source	Swiss-Prot : SWS_FT_FI6

8)	chain	B
	residue	34
	type	CARBOHYD
	sequence	Y
	description	(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269\|PubMed:24141704
	source	Swiss-Prot : SWS_FT_FI7

9)	chain	B
	residue	135
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:23871831
	source	Swiss-Prot : SWS_FT_FI9

10)	chain	B
	residue	160
	type	BINDING
	sequence	S
	description	BINDING => ECO:0000250\|UniProtKB:P62820
	source	Swiss-Prot : SWS_FT_FI2

11)	chain	B
	residue	30
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000250\|UniProtKB:P62820
	source	Swiss-Prot : SWS_FT_FI2

12)	chain	B
	residue	59
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:P62820
	source	Swiss-Prot : SWS_FT_FI2