eF-site ID 1xcg-ABEF
PDB Code 1xcg
Chain A, B, E, F

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Title Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF
Classification SIGNALING PROTEIN ACTIVATOR/SIGNALING PROTEIN
Compound Rho guanine nucleotide exchange factor 11
Source Homo sapiens (Human) (RHOA_HUMAN)
Sequence A:  QNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTL
RVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWC
EAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFC
SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRD
LIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQC
REILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLA
AEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLL
VLLQKQDEKLLLKCTFSPVLKLNAVLIRSVATDKRAFFII
CTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNA
B:  AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENY
VADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILM
CFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLR
NDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAK
TKDGVREVFEMATRAALQ
E:  QNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTL
RVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWC
EAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFC
SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRD
LIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQC
REILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLA
AEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLL
VLLQKQDEKLLLKCHSKTFSPVLKLNAVLIRSVATDKRAF
FIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNA
F:  AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENY
VADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILM
CFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLR
NDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAK
TKDGVREVFEMATRAALQ
Description


Functional site
1) chain B
residue 12
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
source Swiss-Prot : SWS_FT_FI1
2) chain B
residue 117
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
source Swiss-Prot : SWS_FT_FI1
3) chain F
residue 12
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
source Swiss-Prot : SWS_FT_FI1
4) chain F
residue 117
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 30
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
6) chain B
residue 59
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
7) chain B
residue 160
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
8) chain F
residue 30
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
9) chain F
residue 59
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
10) chain F
residue 160
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P62820
source Swiss-Prot : SWS_FT_FI2
11) chain B
residue 34
type MOD_RES
sequence Y
description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
source Swiss-Prot : SWS_FT_FI3
12) chain F
residue 34
type MOD_RES
sequence Y
description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
source Swiss-Prot : SWS_FT_FI3
13) chain B
residue 37
type MOD_RES
sequence T
description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
source Swiss-Prot : SWS_FT_FI4
14) chain F
residue 37
type MOD_RES
sequence T
description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
source Swiss-Prot : SWS_FT_FI4
15) chain B
residue 41
type MOD_RES
sequence N
description (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
source Swiss-Prot : SWS_FT_FI5
16) chain F
residue 41
type MOD_RES
sequence N
description (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
source Swiss-Prot : SWS_FT_FI5
17) chain B
residue 63
type MOD_RES
sequence Q
description 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
source Swiss-Prot : SWS_FT_FI6
18) chain F
residue 63
type MOD_RES
sequence Q
description 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
source Swiss-Prot : SWS_FT_FI6
19) chain B
residue 34
type CARBOHYD
sequence Y
description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI7
20) chain F
residue 34
type CARBOHYD
sequence Y
description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI7
21) chain B
residue 37
type CARBOHYD
sequence T
description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
source Swiss-Prot : SWS_FT_FI8
22) chain F
residue 37
type CARBOHYD
sequence T
description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
source Swiss-Prot : SWS_FT_FI8
23) chain B
residue 135
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
source Swiss-Prot : SWS_FT_FI9
24) chain F
residue 135
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
source Swiss-Prot : SWS_FT_FI9

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