eF-site ID 1x81-B PDB Code 1x81 Chain B click to enlarge Title Farnesyl transferase structure of Jansen compound Classification TRANSFERASE Compound Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit Source ORGANISM_COMMON: Norway rat; ORGANISM_SCIENTIFIC: Rattus norvegicus; Sequence B:  PLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSS YKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRP WLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFG GGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYL YSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDL FEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVI LKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYS FWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILM CCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAM LHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQK Description Functional site 1) chain B residue 297 type sequence D description BINDING SITE FOR RESIDUE ZN B 2 source : AC1 2) chain B residue 299 type sequence C description BINDING SITE FOR RESIDUE ZN B 2 source : AC1 3) chain B residue 362 type sequence H description BINDING SITE FOR RESIDUE ZN B 2 source : AC1 4) chain B residue 102 type sequence W description BINDING SITE FOR RESIDUE JAN B 1 source : AC2 5) chain B residue 106 type sequence W description BINDING SITE FOR RESIDUE JAN B 1 source : AC2 6) chain B residue 297 type sequence D description BINDING SITE FOR RESIDUE JAN B 1 source : AC2 7) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE JAN B 1 source : AC2 8) chain B residue 361 type sequence Y description BINDING SITE FOR RESIDUE JAN B 1 source : AC2 9) chain B residue 248 type catalytic sequence H description 484 source MCSA : MCSA1 10) chain B residue 291 type catalytic sequence R description 484 source MCSA : MCSA1 11) chain B residue 294 type catalytic sequence K description 484 source MCSA : MCSA1 12) chain B residue 297 type catalytic sequence D description 484 source MCSA : MCSA1 13) chain B residue 299 type catalytic sequence C description 484 source MCSA : MCSA1 14) chain B residue 300 type catalytic sequence Y description 484 source MCSA : MCSA1 15) chain B residue 352 type catalytic sequence D description 484 source MCSA : MCSA1 16) chain B residue 359 type catalytic sequence D description 484 source MCSA : MCSA1 17) chain B residue 362 type catalytic sequence H description 484 source MCSA : MCSA1 18) chain B residue 102 type SITE sequence W description Important for selectivity against geranylgeranyl diphosphate => ECO:0000250|UniProtKB:P49356 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 248 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 20) chain B residue 291 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 21) chain B residue 300 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 22) chain B residue 297 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 299 type BINDING sequence C description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 362 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 source Swiss-Prot : SWS_FT_FI2

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