eF-site ID 1wx5-A PDB Code 1wx5 Chain A click to enlarge Title Crystal Structure of the copper-free Streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein in the monoclinic crystal Classification OXIDOREDUCTASE/METAL TRANSPORT Compound tyrosinase Source Streptomyces castaneoglobisporus (Q83WS1_9ACTO) Sequence A:  TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEF IMSDTDSGERTGHRSPSFLPWHRRFLLDFEQALQSVDSSV TLPYWDWSADRTVRASLWAPDFLGGTGRSTDGRVMDGPFA ASTGNWPINVRVDSRTYLRRSLGGSVAELPTRAEVESVLA ISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQM ATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGT PDVVDLNETMKPWNTVRPADLLDHTAYYTFDALEH Description Functional site 1) chain A residue 241 type sequence T description BINDING SITE FOR RESIDUE NA A 282 source : AC2 2) chain A residue 244 type sequence V description BINDING SITE FOR RESIDUE NA A 282 source : AC2 3) chain A residue 246 type sequence D description BINDING SITE FOR RESIDUE NA A 282 source : AC2 4) chain A residue 249 type sequence E description BINDING SITE FOR RESIDUE NA A 282 source : AC2 5) chain A residue 265 type sequence H description BINDING SITE FOR RESIDUE CL A 283 source : AC4 6) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE CL A 283 source : AC4 7) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE CL A 283 source : AC4 8) chain A residue 223 type sequence W description BINDING SITE FOR RESIDUE CL A 284 source : AC5 9) chain A residue 227 type sequence Q description BINDING SITE FOR RESIDUE CL A 284 source : AC5 10) chain A residue 54-71 type prosite sequence HRSPSFLPWHRRFLLDFE description TYROSINASE_1 Tyrosinase CuA-binding region signature. Hrsps.FLpWHRrfLldfE source prosite : PS00497 11) chain A residue 209-220 type prosite sequence DPVFWLHHAYVD description TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPvFWlhHayvD source prosite : PS00498

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