eF-site ID 1wx5-ABCD PDB Code 1wx5 Chain A, B, C, D click to enlarge Title Crystal Structure of the copper-free Streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein in the monoclinic crystal Classification OXIDOREDUCTASE/METAL TRANSPORT Compound tyrosinase Source Streptomyces castaneoglobisporus (Q83WS1_9ACTO) Sequence A:  TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEF IMSDTDSGERTGHRSPSFLPWHRRFLLDFEQALQSVDSSV TLPYWDWSADRTVRASLWAPDFLGGTGRSTDGRVMDGPFA ASTGNWPINVRVDSRTYLRRSLGGSVAELPTRAEVESVLA ISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQM ATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGT PDVVDLNETMKPWNTVRPADLLDHTAYYTFDALEH B:  APESFDEVYKGRRIQGRPAGYEVFVDGVQLHVMRNADGSW ISVVSHYDPVPTPRAAARAAVDELQGAPLLP C:  TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEF IMSDTDSGERTGHRSPSFLPWHRRFLLDFEQALQSVDSSV TLPYWDWSADRTVRASLWAPDFLGGTGRSTDGRVMDGPFA ASTGNWPINVRVDSRTYLRRSLGGSVAELPTRAEVESVLA ISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQM ATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGT PDVVDLNETMKPWNTVRPADLLDHTAYYTFDAL D:  APESFDEVYKGRRIQGRPAEHGGGYEVFVDGVQLHVMRNA DGSWISVVSHYDPVPTPRAAARAAVDELQGAPLLP Description Functional site 1) chain C residue 241 type sequence T description BINDING SITE FOR RESIDUE NA C 282 source : AC1 2) chain C residue 244 type sequence V description BINDING SITE FOR RESIDUE NA C 282 source : AC1 3) chain C residue 246 type sequence D description BINDING SITE FOR RESIDUE NA C 282 source : AC1 4) chain C residue 249 type sequence E description BINDING SITE FOR RESIDUE NA C 282 source : AC1 5) chain A residue 241 type sequence T description BINDING SITE FOR RESIDUE NA A 282 source : AC2 6) chain A residue 244 type sequence V description BINDING SITE FOR RESIDUE NA A 282 source : AC2 7) chain A residue 246 type sequence D description BINDING SITE FOR RESIDUE NA A 282 source : AC2 8) chain A residue 249 type sequence E description BINDING SITE FOR RESIDUE NA A 282 source : AC2 9) chain C residue 50 type sequence E description BINDING SITE FOR RESIDUE NA C 283 source : AC3 10) chain C residue 51 type sequence R description BINDING SITE FOR RESIDUE NA C 283 source : AC3 11) chain C residue 52 type sequence T description BINDING SITE FOR RESIDUE NA C 283 source : AC3 12) chain C residue 243 type sequence D description BINDING SITE FOR RESIDUE NA C 283 source : AC3 13) chain C residue 244 type sequence V description BINDING SITE FOR RESIDUE NA C 283 source : AC3 14) chain A residue 265 type sequence H description BINDING SITE FOR RESIDUE CL A 283 source : AC4 15) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE CL A 283 source : AC4 16) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE CL A 283 source : AC4 17) chain A residue 223 type sequence W description BINDING SITE FOR RESIDUE CL A 284 source : AC5 18) chain A residue 227 type sequence Q description BINDING SITE FOR RESIDUE CL A 284 source : AC5 19) chain A residue 54-71 type prosite sequence HRSPSFLPWHRRFLLDFE description TYROSINASE_1 Tyrosinase CuA-binding region signature. Hrsps.FLpWHRrfLldfE source prosite : PS00497 20) chain A residue 209-220 type prosite sequence DPVFWLHHAYVD description TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPvFWlhHayvD source prosite : PS00498

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