eF-site ID 1wta-A PDB Code 1wta Chain A click to enlarge Title Crystal Structure of 5'-Deoxy-5'-methylthioadenosine from Aeropyrum pernix (R32 form) Classification TRANSFERASE Compound 5'-methylthioadenosine phosphorylase Source (NP_148238) Sequence A:  EITRPPGVRAHVGVIGGSGLYDPGIVENPVEVKVSTPYGN PSDFIVVGDVAGVKVAFLPRHGRGHRIPPHAINYRANIWA LKALGVKWVISVSAVGSLREDYRPGDFVVPDQFIDMTKNR RHYTFYDGPVTVHVSMADPFCEDLRQRLIDSGRRLGYTVH ERGTYVCIEGPRFSTRAESRVWKDVFKADIIGMTLVPEIN LACEAQLCYATLAMVTDYDVWADRPVTAEEVERVMISNVE RARRMLYDVIPKLAGEPELERCSCCRALDTAAI Description (1)  5'-methylthioadenosine phosphorylase (E.C.2.4.2.28) Functional site 1) chain A residue 62 type sequence R description BINDING SITE FOR RESIDUE PO4 A 400 source : AC1 2) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE PO4 A 400 source : AC1 3) chain A residue 95 type sequence S description BINDING SITE FOR RESIDUE PO4 A 400 source : AC1 4) chain A residue 96 type sequence A description BINDING SITE FOR RESIDUE PO4 A 400 source : AC1 5) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE PO4 A 400 source : AC1 6) chain A residue 97 type sequence V description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 7) chain A residue 98 type sequence G description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 8) chain A residue 175 type sequence F description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 9) chain A residue 193 type sequence I description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 10) chain A residue 194 type sequence G description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 11) chain A residue 195 type sequence M description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 12) chain A residue 218 type sequence T description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 13) chain A residue 219 type sequence D description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 14) chain A residue 221 type sequence D description BINDING SITE FOR RESIDUE ADE A 1300 source : AC2 15) chain A residue 60-100 type prosite sequence LPRHGRGHRIPPHAINYRANIWALKALGVKWVISVSAVGS L description PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGrgHrIpphaInyrAn.IwAlkalGvkw.VIsvSAvGSL source prosite : PS01240 16) chain A residue 20 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 62 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 95 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 195 type BINDING sequence M description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 219 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 176 type SITE sequence S description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 230 type SITE sequence A description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01963 source Swiss-Prot : SWS_FT_FI2

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