eF-site ID 1wnt-ABCD PDB Code 1wnt Chain A, B, C, D click to enlarge Title Structure of the tetrameric form of Human L-Xylulose Reductase Classification OXIDOREDUCTASE Compound L-xylulose reductase Source (DCXR_HUMAN) Sequence A:  MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT QADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG FWAC B:  MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT QADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG FWAC C:  MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT QADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG FWAC D:  MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT QADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG FWAC Description Functional site 1) chain A residue 14 type sequence G description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 2) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 3) chain A residue 17 type sequence K description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 4) chain A residue 18 type sequence G description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 5) chain A residue 19 type sequence I description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 6) chain A residue 38 type sequence S description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 7) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 8) chain A residue 40 type sequence T description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 9) chain A residue 59 type sequence V description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 10) chain A residue 60 type sequence D description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 11) chain A residue 61 type sequence L description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 12) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 13) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 14) chain A residue 85 type sequence A description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 15) chain A residue 102 type sequence R description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 16) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 17) chain A residue 134 type sequence V description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 18) chain A residue 135 type sequence S description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 19) chain A residue 149 type sequence Y description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 20) chain A residue 153 type sequence K description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 21) chain A residue 179 type sequence P description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 22) chain A residue 180 type sequence T description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 23) chain A residue 181 type sequence V description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 24) chain A residue 182 type sequence V description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 25) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 26) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 27) chain A residue 186 type sequence M description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 28) chain A residue 187 type sequence G description BINDING SITE FOR RESIDUE NAP A 245 source : AC1 29) chain B residue 14 type sequence G description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 30) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 31) chain B residue 17 type sequence K description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 32) chain B residue 18 type sequence G description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 33) chain B residue 19 type sequence I description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 34) chain B residue 38 type sequence S description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 35) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 36) chain B residue 40 type sequence T description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 37) chain B residue 59 type sequence V description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 38) chain B residue 60 type sequence D description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 39) chain B residue 61 type sequence L description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 40) chain B residue 62 type sequence G description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 41) chain B residue 83 type sequence N description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 42) chain B residue 85 type sequence A description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 43) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 44) chain B residue 134 type sequence V description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 45) chain B residue 149 type sequence Y description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 46) chain B residue 153 type sequence K description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 47) chain B residue 180 type sequence T description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 48) chain B residue 182 type sequence V description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 49) chain B residue 184 type sequence T description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 50) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 51) chain B residue 186 type sequence M description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 52) chain B residue 187 type sequence G description BINDING SITE FOR RESIDUE NAP B 1245 source : AC2 53) chain C residue 14 type sequence G description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 54) chain C residue 16 type sequence G description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 55) chain C residue 17 type sequence K description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 56) chain C residue 18 type sequence G description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 57) chain C residue 19 type sequence I description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 58) chain C residue 38 type sequence S description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 59) chain C residue 39 type sequence R description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 60) chain C residue 40 type sequence T description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 61) chain C residue 43 type sequence D description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 62) chain C residue 59 type sequence V description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 63) chain C residue 61 type sequence L description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 64) chain C residue 83 type sequence N description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 65) chain C residue 85 type sequence A description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 66) chain C residue 106 type sequence V description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 67) chain C residue 134 type sequence V description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 68) chain C residue 149 type sequence Y description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 69) chain C residue 153 type sequence K description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 70) chain C residue 179 type sequence P description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 71) chain C residue 180 type sequence T description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 72) chain C residue 181 type sequence V description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 73) chain C residue 182 type sequence V description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 74) chain C residue 184 type sequence T description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 75) chain C residue 186 type sequence M description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 76) chain C residue 187 type sequence G description BINDING SITE FOR RESIDUE NAP C 2245 source : AC3 77) chain D residue 14 type sequence G description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 78) chain D residue 16 type sequence G description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 79) chain D residue 17 type sequence K description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 80) chain D residue 18 type sequence G description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 81) chain D residue 19 type sequence I description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 82) chain D residue 38 type sequence S description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 83) chain D residue 39 type sequence R description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 84) chain D residue 40 type sequence T description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 85) chain D residue 43 type sequence D description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 86) chain D residue 59 type sequence V description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 87) chain D residue 61 type sequence L description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 88) chain D residue 83 type sequence N description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 89) chain D residue 84 type sequence A description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 90) chain D residue 85 type sequence A description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 91) chain D residue 102 type sequence R description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 92) chain D residue 106 type sequence V description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 93) chain D residue 134 type sequence V description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 94) chain D residue 135 type sequence S description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 95) chain D residue 149 type sequence Y description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 96) chain D residue 153 type sequence K description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 97) chain D residue 179 type sequence P description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 98) chain D residue 180 type sequence T description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 99) chain D residue 181 type sequence V description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 100) chain D residue 182 type sequence V description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 101) chain D residue 184 type sequence T description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 102) chain D residue 185 type sequence S description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 103) chain D residue 186 type sequence M description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 104) chain D residue 187 type sequence G description BINDING SITE FOR RESIDUE NAP D 3245 source : AC4 105) chain A residue 21 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI4 106) chain B residue 21 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI4 107) chain C residue 21 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI4 108) chain D residue 21 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI4 109) chain A residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 110) chain B residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 111) chain C residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 112) chain D residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 113) chain A residue 136-164 type prosite sequence SQCSQRAVTNHSVYCSTKGALDMLTKVMA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SqcsqravtnHsvYCSTKGALdMLTkVMA source prosite : PS00061 114) chain A residue 149 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 115) chain B residue 149 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 116) chain C residue 149 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 117) chain D residue 149 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI1 118) chain A residue 11 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 119) chain D residue 11 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 120) chain D residue 136 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 121) chain D residue 153 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 122) chain A residue 136 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 123) chain A residue 153 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 124) chain B residue 11 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 125) chain B residue 136 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 126) chain B residue 153 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 127) chain C residue 11 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 128) chain C residue 136 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 129) chain C residue 153 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15103634 source Swiss-Prot : SWS_FT_FI2 130) chain A residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 source Swiss-Prot : SWS_FT_FI3 131) chain B residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 source Swiss-Prot : SWS_FT_FI3 132) chain C residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 source Swiss-Prot : SWS_FT_FI3 133) chain D residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 source Swiss-Prot : SWS_FT_FI3

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