|
|
eF-site ID
|
1wmn-A |
|
PDB Code
|
1wmn |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Crystal structure of topaquinone-containing amine oxidase activated by cobalt ion |
|
Classification
|
OXIDOREDUCTASE |
|
Compound
|
Phenylethylamine oxidase |
|
Source
|
null (PAOX_ARTGO) |
|
|
Sequence
|
A: |
ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPA
RGAGSEAEDRRFRVFIHDVSGARPQEVTVSVTNGTVISAV
ELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLD
VSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAW
AHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE
LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVG
FDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPS
PIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVI
SDAFGNPREIRNGICMHEEDWGILAKHSDLWSGINYTRRN
RRMVISFFTTIGNXDYGFYWYLYLDGTIEFEAKATGVVFT
SAFPEGGSDNISQLAPGLGAPFHQHIFSARLDMAIDGFTN
RVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREAD
ARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGS
SIARRAAFATKDLWVTRYADDERYPTGDFVNQHSGGAGLP
SYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVG
FKLRPEGFFDRSPVLDVPAN
|
|
|
Description
|
(1) |
Phenylethylamine oxidase (E.C.1.4.3.6)
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
431 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CO A 1001
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
433 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CO A 1001
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
592 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CO A 1001
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
298 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
382 |
| type |
ACT_SITE |
| sequence |
X
|
| description |
Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
296 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
379 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000250|UniProtKB:P46883
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
A |
| residue |
371-384 |
| type |
prosite |
| sequence |
MVISFFTTIGNXDY
|
| description |
COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY
|
| source |
prosite : PS01164
|
|
|
9)
|
chain |
A |
| residue |
587-600 |
| type |
prosite |
| sequence |
TFGLTHFPRVEDWP
|
| description |
COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP
|
| source |
prosite : PS01165
|
|
|
10)
|
chain |
A |
| residue |
382 |
| type |
MOD_RES |
| sequence |
X
|
| description |
2',4',5'-topaquinone => ECO:0000269|PubMed:9405045
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
11)
|
chain |
A |
| residue |
431 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
12)
|
chain |
A |
| residue |
433 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
13)
|
chain |
A |
| residue |
592 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|