eF-site ID 1wcm-A PDB Code 1wcm Chain A click to enlarge Title Complete 12-Subunit RNA Polymerase II at 3.8 Angstrom Classification TRANSCRIPTION Compound DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT Source ORGANISM_COMMON: YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence A:  VGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETM DETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHF GHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNEL MRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQL VSRGGCGNTQPTIRKDGLKLVGSWKDEPELRVLSTEEILN IFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPS ISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAI EEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARL KGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKS IAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDS GDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPS LHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNL HVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLC GIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPK PLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIID GQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNI QKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKK VLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKA GRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQS VEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLT PQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIM VHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGS DAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLL DEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQ TFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQN AQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNI EAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLKKVTSGVP RLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIE HTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLQQS PWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWS EDNDEKLIIRCRVVAEEDHMLKKIENTMLENITLRGVENI ERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTV PGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASD GSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMR CSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTG AFDVMIDEESLVKYMP Description (1)  DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SECOND LARGEST SUBUNIT (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 45 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 27 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 23 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 14.5 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 14.2 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II AND III 8.3 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 7.7 KDA POLYPEPTIDE (E.C.2.7.7.6) Functional site 1) chain A residue 108 type sequence M description BINDING SITE FOR RESIDUE ZN A2456 source : AC1 2) chain A residue 110 type sequence C description BINDING SITE FOR RESIDUE ZN A2456 source : AC1 3) chain A residue 148 type sequence C description BINDING SITE FOR RESIDUE ZN A2456 source : AC1 4) chain A residue 167 type sequence C description BINDING SITE FOR RESIDUE ZN A2456 source : AC1 5) chain A residue 67 type sequence C description BINDING SITE FOR RESIDUE ZN A2457 source : AC2 6) chain A residue 70 type sequence C description BINDING SITE FOR RESIDUE ZN A2457 source : AC2 7) chain A residue 77 type sequence C description BINDING SITE FOR RESIDUE ZN A2457 source : AC2 8) chain A residue 80 type sequence H description BINDING SITE FOR RESIDUE ZN A2457 source : AC2 9) chain A residue 481 type sequence D description BINDING SITE FOR RESIDUE MG A2458 source : AC3 10) chain A residue 483 type sequence D description BINDING SITE FOR RESIDUE MG A2458 source : AC3 11) chain A residue 485 type sequence D description BINDING SITE FOR RESIDUE MG A2458 source : AC3 12) chain A residue 483 type catalytic sequence D description 788 source MCSA : MCSA1 13) chain A residue 485 type catalytic sequence D description 788 source MCSA : MCSA1 14) chain A residue 483 type ZN_FING sequence D description C4-type source Swiss-Prot : SWS_FT_FI1 15) chain A residue 485 type ZN_FING sequence D description C4-type source Swiss-Prot : SWS_FT_FI1 16) chain A residue 107 type ZN_FING sequence C description C4-type source Swiss-Prot : SWS_FT_FI1 17) chain A residue 110 type ZN_FING sequence C description C4-type source Swiss-Prot : SWS_FT_FI1 18) chain A residue 148 type ZN_FING sequence C description C4-type source Swiss-Prot : SWS_FT_FI1 19) chain A residue 167 type ZN_FING sequence C description C4-type source Swiss-Prot : SWS_FT_FI1 20) chain A residue 481 type ZN_FING sequence D description C4-type source Swiss-Prot : SWS_FT_FI1

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