|
|
eF-site ID
|
1wcm-B |
|
PDB Code
|
1wcm |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Complete 12-Subunit RNA Polymerase II at 3.8 Angstrom |
|
Classification
|
TRANSCRIPTION |
|
Compound
|
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT |
|
Source
|
ORGANISM_COMMON: YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; |
|
|
Sequence
|
B: |
DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTL
QDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEAR
LRNLTYSSGLFVDVKKKVFIGRLPIMLRSKNCYLSEATES
DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK
KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR
TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND
WQMLEMLKPCVEDGFVIQDRETALDFIGKEKRIQYAKDIL
QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQD
DRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV
ELAINAKTITSGLKYALATGNWGAGVSQVLNRYTYSSTLS
HLRRTNTPIAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATR
VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDI
REKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIA
KLMATEYQDEYTWSSLLNEGLVEYIDAEEEESILIAMQPE
DLEPAEADVDPAKRIRVSHHATTFTHCEIHPSMILGVAAS
IIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMAN
ILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYN
QEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETF
EKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGK
TTPISSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVR
VRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIV
PDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPF
TDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFF
GPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGG
LRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICG
LMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQEL
MAMNITPRLYTDRSRDF
|
|
|
Description
|
(1) |
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SECOND LARGEST SUBUNIT (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 45 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 32 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 27 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 23 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 14.5 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 14.2 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II AND III 8.3 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I, II, AND III 7.7 KDA POLYPEPTIDE (E.C.2.7.7.6)
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
1163 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B2225
|
| source |
: AC4
|
|
|
2)
|
chain |
B |
| residue |
1166 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B2225
|
| source |
: AC4
|
|
|
3)
|
chain |
B |
| residue |
1182 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B2225
|
| source |
: AC4
|
|
|
4)
|
chain |
B |
| residue |
1185 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B2225
|
| source |
: AC4
|
|
|
5)
|
chain |
B |
| residue |
977-989 |
| type |
prosite |
| sequence |
GDKFASRHGQKGT
|
| description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
|
| source |
prosite : PS01166
|
|
|
6)
|
chain |
B |
| residue |
837 |
| type |
catalytic |
| sequence |
D
|
| description |
788
|
| source |
MCSA : MCSA1
|
|
|
7)
|
chain |
B |
| residue |
1185 |
| type |
BINDING |
| sequence |
C
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|