eF-site ID 1wao-4 PDB Code 1wao Chain 4 click to enlarge Title PP5 structure Classification HYDROLASE Compound SERINE/THREONINE PROTEIN PHOSPHATASE 5 Source Homo sapiens (Human) (PPP5_HUMAN) Sequence 4:  GALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNA IYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRR AASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKI VKQKAFERAKRSVVDSLDIESMTIEDEYSGPKLEDGKVTI SFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVE TTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIF NGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDN MNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKV LIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSD PQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHE VKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSD LRPQFHQFTAVPHPNVKPMAYANTLL Description (1)  SERINE/THREONINE PROTEIN PHOSPHATASE 5 (E.C.3.1.3.16) Functional site 1) chain 4 residue 242 type sequence D description BINDING SITE FOR RESIDUE MN 4 601 source : AC7 2) chain 4 residue 271 type sequence D description BINDING SITE FOR RESIDUE MN 4 601 source : AC7 3) chain 4 residue 303 type sequence N description BINDING SITE FOR RESIDUE MN 4 601 source : AC7 4) chain 4 residue 352 type sequence H description BINDING SITE FOR RESIDUE MN 4 601 source : AC7 5) chain 4 residue 427 type sequence H description BINDING SITE FOR RESIDUE MN 4 601 source : AC7 6) chain 4 residue 76 type sequence E description BINDING SITE FOR RESIDUE MN 4 602 source : AC8 7) chain 4 residue 242 type sequence D description BINDING SITE FOR RESIDUE MN 4 602 source : AC8 8) chain 4 residue 244 type sequence H description BINDING SITE FOR RESIDUE MN 4 602 source : AC8 9) chain 4 residue 271 type sequence D description BINDING SITE FOR RESIDUE MN 4 602 source : AC8 10) chain 4 residue 275 type sequence R description BINDING SITE FOR RESIDUE MN 4 602 source : AC8 11) chain 4 residue 242 type catalytic sequence D description 472 source MCSA : MCSA4 12) chain 4 residue 427 type catalytic sequence H description 472 source MCSA : MCSA4 13) chain 4 residue 244 type catalytic sequence H description 472 source MCSA : MCSA4 14) chain 4 residue 271 type catalytic sequence D description 472 source MCSA : MCSA4 15) chain 4 residue 274 type catalytic sequence D description 472 source MCSA : MCSA4 16) chain 4 residue 275 type catalytic sequence R description 472 source MCSA : MCSA4 17) chain 4 residue 303 type catalytic sequence N description 472 source MCSA : MCSA4 18) chain 4 residue 304 type catalytic sequence H description 472 source MCSA : MCSA4 19) chain 4 residue 352 type catalytic sequence H description 472 source MCSA : MCSA4 20) chain 4 residue 400 type catalytic sequence R description 472 source MCSA : MCSA4 21) chain 4 residue 304 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI1 22) chain 4 residue 242 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 23) chain 4 residue 271 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 24) chain 4 residue 303 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 25) chain 4 residue 352 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 26) chain 4 residue 244 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 27) chain 4 residue 275 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 28) chain 4 residue 400 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 29) chain 4 residue 427 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3

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