eF-site ID 1wao-1 PDB Code 1wao Chain 1 click to enlarge Title PP5 structure Classification HYDROLASE Compound SERINE/THREONINE PROTEIN PHOSPHATASE 5 Source null (PPP5_HUMAN) Sequence 1:  GALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNA IYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRR AASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKI VKQKAFERAKRSVVDSLDIESMTIEDEYSGPKLEDGKVTI SFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVE TTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIF NGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDN MNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKV LIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSD PQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHE VKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSD LRPQFHQFTAVPHPNVKPMAYANTLLQLGMM Description (1)  SERINE/THREONINE PROTEIN PHOSPHATASE 5 (E.C.3.1.3.16) Functional site 1) chain 1 residue 271 type sequence D description BINDING SITE FOR RESIDUE MN 1 601 source : AC1 2) chain 1 residue 303 type sequence N description BINDING SITE FOR RESIDUE MN 1 601 source : AC1 3) chain 1 residue 352 type sequence H description BINDING SITE FOR RESIDUE MN 1 601 source : AC1 4) chain 1 residue 427 type sequence H description BINDING SITE FOR RESIDUE MN 1 601 source : AC1 5) chain 1 residue 242 type sequence D description BINDING SITE FOR RESIDUE MN 1 602 source : AC2 6) chain 1 residue 244 type sequence H description BINDING SITE FOR RESIDUE MN 1 602 source : AC2 7) chain 1 residue 271 type sequence D description BINDING SITE FOR RESIDUE MN 1 602 source : AC2 8) chain 1 residue 451 type sequence Y description BINDING SITE FOR RESIDUE MN 1 602 source : AC2 9) chain 1 residue 304 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI1 10) chain 1 residue 300-305 type prosite sequence LRGNHE description SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE source prosite : PS00125 11) chain 1 residue 242 type catalytic sequence D description 472 source MCSA : MCSA1 12) chain 1 residue 244 type catalytic sequence H description 472 source MCSA : MCSA1 13) chain 1 residue 271 type catalytic sequence D description 472 source MCSA : MCSA1 14) chain 1 residue 274 type catalytic sequence D description 472 source MCSA : MCSA1 15) chain 1 residue 275 type catalytic sequence R description 472 source MCSA : MCSA1 16) chain 1 residue 303 type catalytic sequence N description 472 source MCSA : MCSA1 17) chain 1 residue 304 type catalytic sequence H description 472 source MCSA : MCSA1 18) chain 1 residue 352 type catalytic sequence H description 472 source MCSA : MCSA1 19) chain 1 residue 400 type catalytic sequence R description 472 source MCSA : MCSA1 20) chain 1 residue 427 type catalytic sequence H description 472 source MCSA : MCSA1 21) chain 1 residue 242 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 22) chain 1 residue 271 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 23) chain 1 residue 303 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 24) chain 1 residue 352 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 25) chain 1 residue 427 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 26) chain 1 residue 244 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 27) chain 1 residue 275 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 28) chain 1 residue 400 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3

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