eF-site ID 1w8n-A PDB Code 1w8n Chain A click to enlarge Title Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens. Classification HYDROLASE Compound BACTERIAL SIALIDASE Source Micromonospora viridifaciens (NANH_MICVI) Sequence A:  GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDG RPTGIGAPGPNSILQRRSTDGGRTWGEQQVVSAGQTTAPI KGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPAD PNVLHANVATSTDGGLTWSHRTITADITPDPGWRSRFAAS GEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGR TWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKV AVSTDGGHSYGPVTIDRDLPDPTNNASIIRAFPDAPAGSA RAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVSKVFQPG SMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICA PFTIPDVALEPGQQVTVPVAVTNQSGIAVPKPSLQLDASP DWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRYRVGATL RTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRA SNVIDGNPSTFWHTEWSRADAPGYPHRISLDLGGTHTISG LQYTRRQNSANEQVADYEIYTSLNGTTWDGPVASGRFTTS LAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQ R Description Functional site 1) chain A residue 92 type catalytic sequence G description 835 source MCSA : MCSA1 2) chain A residue 260 type catalytic sequence E description 835 source MCSA : MCSA1 3) chain A residue 370 type catalytic sequence Y description 835 source MCSA : MCSA1 4) chain A residue 92 type ACT_SITE sequence G description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 260 type ACT_SITE sequence E description Nucleophile => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 370 type ACT_SITE sequence Y description Nucleophile source Swiss-Prot : SWS_FT_FI3 7) chain A residue 68 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 8) chain A residue 276 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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