eF-site ID 1w8n-A
PDB Code 1w8n
Chain A

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Title Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens.
Classification HYDROLASE
Compound BACTERIAL SIALIDASE
Source Micromonospora viridifaciens (NANH_MICVI)
Sequence A:  GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDG
RPTGIGAPGPNSILQRRSTDGGRTWGEQQVVSAGQTTAPI
KGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPAD
PNVLHANVATSTDGGLTWSHRTITADITPDPGWRSRFAAS
GEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGR
TWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKV
AVSTDGGHSYGPVTIDRDLPDPTNNASIIRAFPDAPAGSA
RAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVSKVFQPG
SMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICA
PFTIPDVALEPGQQVTVPVAVTNQSGIAVPKPSLQLDASP
DWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRYRVGATL
RTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRA
SNVIDGNPSTFWHTEWSRADAPGYPHRISLDLGGTHTISG
LQYTRRQNSANEQVADYEIYTSLNGTTWDGPVASGRFTTS
LAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQ
R
Description


Functional site

1) chain A
residue 92
type catalytic
sequence G
description 835
source MCSA : MCSA1

2) chain A
residue 260
type catalytic
sequence E
description 835
source MCSA : MCSA1

3) chain A
residue 370
type catalytic
sequence Y
description 835
source MCSA : MCSA1

4) chain A
residue 92
type ACT_SITE
sequence G
description Proton acceptor => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 260
type ACT_SITE
sequence E
description Nucleophile => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 370
type ACT_SITE
sequence Y
description Nucleophile
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 68
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 276
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI4


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