eF-site ID 1w85-G PDB Code 1w85 Chain G click to enlarge Title The crystal structure of pyruvate dehydrogenase E1 bound to the peripheral subunit binding domain of E2 Classification OXIDOREDUCTASE Compound PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT Source (ODP2_BACST) Sequence G:  FQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSDE QLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEAS QIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSRG HFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGKK AVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNRF AISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYAA VKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRSK ELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKEE IKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYKE KESK Description Functional site 1) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE MG G1368 source : AC9 2) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE MG G1368 source : AC9 3) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE MG G1368 source : AC9 4) chain G residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 5) chain G residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 6) chain G residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 7) chain G residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 8) chain G residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 9) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 10) chain G residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 11) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 12) chain G residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 13) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 14) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 15) chain G residue 205 type sequence A description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 16) chain G residue 206 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 17) chain G residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 18) chain G residue 109 type sequence I description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 19) chain G residue 110 type sequence W description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 20) chain G residue 324 type sequence E description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 21) chain G residue 282 type catalytic sequence R description 106 source MCSA : MCSA4

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