eF-site ID 1w85-F PDB Code 1w85 Chain F click to enlarge Title The crystal structure of pyruvate dehydrogenase E1 bound to the peripheral subunit binding domain of E2 Classification OXIDOREDUCTASE Compound PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT Source (ODP2_BACST) Sequence F:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF Description Functional site 1) chain F residue 112 type sequence I description BINDING SITE FOR RESIDUE K F1325 source : AC7 2) chain F residue 113 type sequence T description BINDING SITE FOR RESIDUE K F1325 source : AC7 3) chain F residue 160 type sequence A description BINDING SITE FOR RESIDUE K F1325 source : AC7 4) chain F residue 163 type sequence D description BINDING SITE FOR RESIDUE K F1325 source : AC7 5) chain F residue 165 type sequence D description BINDING SITE FOR RESIDUE K F1325 source : AC7 6) chain F residue 28 type sequence E description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 7) chain F residue 57 type sequence L description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 8) chain F residue 59 type sequence E description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 9) chain F residue 81 type sequence Q description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 10) chain F residue 85 type sequence F description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 11) chain F residue 60 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain F residue 60 type catalytic sequence S description 106 source MCSA : MCSA3 13) chain F residue 129 type catalytic sequence S description 106 source MCSA : MCSA3

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