eF-site ID 1w85-EFGHJ PDB Code 1w85 Chain E, F, G, H, J click to enlarge Title The crystal structure of pyruvate dehydrogenase E1 bound to the peripheral subunit binding domain of E2 Classification OXIDOREDUCTASE Compound PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT Source (ODP2_BACST) Sequence E:  FQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSDE QLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEAS QIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSRG HFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGKK AVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNRK QTVAKTLAQKAVAAGIPGIQVDGMDPLAVYAAVKAARERA INGEGPTLIETLCFRYGPHTMSGDDKELENEWAKKDPLVR FRKFLEAKGLWSEEEENNVIEQAKEEIKEAIKKADETPKQ KVTDLISIMFEELPFNLKEQYEIYKEKESK F:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF G:  FQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSDE QLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEAS QIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSRG HFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGKK AVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNRF AISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYAA VKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRSK ELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKEE IKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYKE KESK H:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF J:  VIAMPSVRKYAREKGVDIGTGKNGRVLKEDIDAFL Description Functional site 1) chain E residue 173 type sequence D description BINDING SITE FOR RESIDUE MG E1368 source : AC6 2) chain E residue 202 type sequence N description BINDING SITE FOR RESIDUE MG E1368 source : AC6 3) chain F residue 112 type sequence I description BINDING SITE FOR RESIDUE K F1325 source : AC7 4) chain F residue 113 type sequence T description BINDING SITE FOR RESIDUE K F1325 source : AC7 5) chain F residue 160 type sequence A description BINDING SITE FOR RESIDUE K F1325 source : AC7 6) chain F residue 163 type sequence D description BINDING SITE FOR RESIDUE K F1325 source : AC7 7) chain F residue 165 type sequence D description BINDING SITE FOR RESIDUE K F1325 source : AC7 8) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE MG G1368 source : AC9 9) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE MG G1368 source : AC9 10) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE MG G1368 source : AC9 11) chain H residue 112 type sequence I description BINDING SITE FOR RESIDUE K H1325 source : BC1 12) chain H residue 113 type sequence T description BINDING SITE FOR RESIDUE K H1325 source : BC1 13) chain H residue 160 type sequence A description BINDING SITE FOR RESIDUE K H1325 source : BC1 14) chain H residue 163 type sequence D description BINDING SITE FOR RESIDUE K H1325 source : BC1 15) chain H residue 165 type sequence D description BINDING SITE FOR RESIDUE K H1325 source : BC1 16) chain E residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 17) chain E residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 18) chain E residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 19) chain E residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 20) chain E residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 21) chain E residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 22) chain E residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 23) chain E residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 24) chain E residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 25) chain E residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 26) chain E residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 27) chain H residue 28 type sequence E description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 28) chain H residue 57 type sequence L description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 29) chain H residue 59 type sequence E description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 30) chain H residue 81 type sequence Q description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 31) chain H residue 85 type sequence F description BINDING SITE FOR RESIDUE TDP E1370 source : BC4 32) chain F residue 28 type sequence E description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 33) chain F residue 57 type sequence L description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 34) chain F residue 59 type sequence E description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 35) chain F residue 81 type sequence Q description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 36) chain F residue 85 type sequence F description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 37) chain G residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 38) chain G residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 39) chain G residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 40) chain G residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 41) chain G residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 42) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 43) chain G residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 44) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 45) chain G residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 46) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 47) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 48) chain G residue 205 type sequence A description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 49) chain G residue 206 type sequence I description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 50) chain G residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP G1370 source : BC5 51) chain G residue 109 type sequence I description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 52) chain G residue 110 type sequence W description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 53) chain G residue 324 type sequence E description BINDING SITE FOR RESIDUE PEG G1369 source : BC8 54) chain F residue 60 type catalytic sequence S description 106 source MCSA : MCSA3 55) chain F residue 129 type catalytic sequence S description 106 source MCSA : MCSA3 56) chain H residue 60 type catalytic sequence S description 106 source MCSA : MCSA4 57) chain H residue 129 type catalytic sequence S description 106 source MCSA : MCSA4 58) chain G residue 282 type catalytic sequence R description 106 source MCSA : MCSA4 59) chain F residue 60 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 60) chain H residue 60 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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