eF-site ID 1w85-ABCDI PDB Code 1w85 Chain A, B, C, D, I click to enlarge Title The crystal structure of pyruvate dehydrogenase E1 bound to the peripheral subunit binding domain of E2 Classification OXIDOREDUCTASE Compound PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT Source (ODP2_BACST) Sequence A:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDSKELENE WAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKEEIKEAI KKADETPKQKVTDLISIMFEELPFNLKEQYEIYKEKESK B:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF C:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRS KELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKE EIKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYK EKESK D:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF I:  RVIAMPSVRKYAREKGVDIRLVQGTGKNGRVLKEDIDAFL AG Description Functional site 1) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE MG A1368 source : AC1 2) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE MG A1368 source : AC1 3) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE MG A1368 source : AC1 4) chain B residue 112 type sequence I description BINDING SITE FOR RESIDUE K B1325 source : AC2 5) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE K B1325 source : AC2 6) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE K B1325 source : AC2 7) chain B residue 163 type sequence D description BINDING SITE FOR RESIDUE K B1325 source : AC2 8) chain B residue 165 type sequence D description BINDING SITE FOR RESIDUE K B1325 source : AC2 9) chain C residue 173 type sequence D description BINDING SITE FOR RESIDUE MG C1368 source : AC4 10) chain C residue 202 type sequence N description BINDING SITE FOR RESIDUE MG C1368 source : AC4 11) chain C residue 204 type sequence F description BINDING SITE FOR RESIDUE MG C1368 source : AC4 12) chain D residue 112 type sequence I description BINDING SITE FOR RESIDUE K D1325 source : AC5 13) chain D residue 113 type sequence T description BINDING SITE FOR RESIDUE K D1325 source : AC5 14) chain D residue 160 type sequence A description BINDING SITE FOR RESIDUE K D1325 source : AC5 15) chain D residue 163 type sequence D description BINDING SITE FOR RESIDUE K D1325 source : AC5 16) chain D residue 165 type sequence D description BINDING SITE FOR RESIDUE K D1325 source : AC5 17) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 18) chain A residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 19) chain A residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 20) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 21) chain A residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 22) chain A residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 23) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 24) chain A residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 25) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 26) chain A residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 27) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 28) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 29) chain A residue 205 type sequence A description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 30) chain A residue 206 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 31) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 32) chain D residue 28 type sequence E description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 33) chain D residue 57 type sequence L description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 34) chain D residue 59 type sequence E description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 35) chain D residue 81 type sequence Q description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 36) chain D residue 85 type sequence F description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 37) chain B residue 28 type sequence E description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 38) chain B residue 57 type sequence L description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 39) chain B residue 59 type sequence E description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 40) chain B residue 81 type sequence Q description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 41) chain B residue 85 type sequence F description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 42) chain C residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 43) chain C residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 44) chain C residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 45) chain C residue 143 type sequence I description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 46) chain C residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 47) chain C residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 48) chain C residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 49) chain C residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 50) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 51) chain C residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 52) chain C residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 53) chain C residue 204 type sequence F description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 54) chain C residue 205 type sequence A description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 55) chain C residue 206 type sequence I description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 56) chain C residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP C1370 source : BC3 57) chain A residue 160 type sequence M description BINDING SITE FOR RESIDUE PEG A1369 source : BC6 58) chain A residue 191 type sequence F description BINDING SITE FOR RESIDUE PEG A1369 source : BC6 59) chain B residue 49 type sequence E description BINDING SITE FOR RESIDUE PEG A1369 source : BC6 60) chain C residue 160 type sequence M description BINDING SITE FOR RESIDUE PEG C1369 source : BC7 61) chain C residue 191 type sequence F description BINDING SITE FOR RESIDUE PEG C1369 source : BC7 62) chain D residue 49 type sequence E description BINDING SITE FOR RESIDUE PEG C1369 source : BC7 63) chain B residue 60 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 64) chain D residue 60 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 60 type catalytic sequence S description 106 source MCSA : MCSA1 66) chain B residue 129 type catalytic sequence S description 106 source MCSA : MCSA1 67) chain D residue 60 type catalytic sequence S description 106 source MCSA : MCSA2 68) chain D residue 129 type catalytic sequence S description 106 source MCSA : MCSA2 69) chain C residue 282 type catalytic sequence R description 106 source MCSA : MCSA2

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