eF-site ID 1w85-A PDB Code 1w85 Chain A click to enlarge Title The crystal structure of pyruvate dehydrogenase E1 bound to the peripheral subunit binding domain of E2 Classification OXIDOREDUCTASE Compound PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT Source (ODP2_BACST) Sequence A:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDSKELENE WAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKEEIKEAI KKADETPKQKVTDLISIMFEELPFNLKEQYEIYKEKESK Description Functional site 1) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE MG A1368 source : AC1 2) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE MG A1368 source : AC1 3) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE MG A1368 source : AC1 4) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 5) chain A residue 103 type sequence R description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 6) chain A residue 142 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 7) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 8) chain A residue 144 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 9) chain A residue 172 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 10) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 11) chain A residue 174 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 12) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 13) chain A residue 178 type sequence Q description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 14) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 15) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 16) chain A residue 205 type sequence A description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 17) chain A residue 206 type sequence I description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 18) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE TDP A1370 source : BC2 19) chain A residue 160 type sequence M description BINDING SITE FOR RESIDUE PEG A1369 source : BC6 20) chain A residue 191 type sequence F description BINDING SITE FOR RESIDUE PEG A1369 source : BC6

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