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eF-site ID
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1w1i-C |
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PDB Code
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1w1i |
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Chain
|
C |
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click to enlarge
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Title
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Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase |
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Classification
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HYDROLASE |
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Compound
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DIPEPTIDYL PEPTIDASE IV |
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Source
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ORGANISM_COMMON: BOVINE; ORGANISM_SCIENTIFIC: BOS TAURUS; |
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Sequence
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C: |
SRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILV
FNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEY
NYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWS
PVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGI
TDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEY
SFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSS
VTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRR
IQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFR
PSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFIT
KGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSD
YTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLP
LYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFII
LNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTV
FRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRL
GTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSM
VLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPED
NLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQ
ISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHF
IKQCFSLP
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Description
|
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Functional site
|
|
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1)
|
chain |
C |
| residue |
547 |
| type |
catalytic |
| sequence |
Y
|
| description |
169
|
| source |
MCSA : MCSA3
|
|
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2)
|
chain |
C |
| residue |
630 |
| type |
catalytic |
| sequence |
S
|
| description |
169
|
| source |
MCSA : MCSA3
|
|
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3)
|
chain |
C |
| residue |
631 |
| type |
catalytic |
| sequence |
Y
|
| description |
169
|
| source |
MCSA : MCSA3
|
|
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4)
|
chain |
C |
| residue |
708 |
| type |
catalytic |
| sequence |
D
|
| description |
169
|
| source |
MCSA : MCSA3
|
|
|
5)
|
chain |
C |
| residue |
740 |
| type |
catalytic |
| sequence |
H
|
| description |
169
|
| source |
MCSA : MCSA3
|
|
|
6)
|
chain |
C |
| residue |
630 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Proton donor => ECO:0000250|UniProtKB:P03958
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
C |
| residue |
708 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton donor => ECO:0000250|UniProtKB:P03958
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
C |
| residue |
740 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Proton donor => ECO:0000250|UniProtKB:P03958
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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