|
|
eF-site ID
|
1vgu-AB |
|
PDB Code
|
1vgu |
|
Chain
|
A, B |
|
click to enlarge
|
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Title
|
Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol synthase |
|
Classification
|
TRANSFERASE |
|
Compound
|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
|
Source
|
Escherichia coli (strain K12) (ISPD_ECOLI) |
|
|
Sequence
|
A: |
LDVCAVVPACPKQYLSIGNQTILEHSVHALLAHPRVKRVV
IAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKA
AGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAA
PVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLH
DCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVT
RPEDLALAEFYLTR
|
| B: |
VCAVVPAQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQ
LQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLH
QDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAH
TVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEAS
ALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTR
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
28 |
| type |
SITE |
| sequence |
Q
|
| description |
Transition state stabilizer => ECO:0000269|PubMed:11427897
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
158 |
| type |
SITE |
| sequence |
N
|
| description |
Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
214 |
| type |
SITE |
| sequence |
V
|
| description |
Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
158 |
| type |
SITE |
| sequence |
N
|
| description |
Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
214 |
| type |
SITE |
| sequence |
V
|
| description |
Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
102-109 |
| type |
prosite |
| sequence |
VLVHDAAR
|
| description |
ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR
|
| source |
prosite : PS01295
|
|
|
|