eF-site ID 1v3u-B PDB Code 1v3u Chain B click to enlarge Title Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase in apo form Classification OXIDOREDUCTASE Compound leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase Source Cavia porcellus (Guinea pig) (Q9EQZ5_CAVPO) Sequence B:  PEFMVKAKSWTLKKHFQGKPTQSDFELKTVELPPLKNGEV LLEALFLSVDPYMRIASKRLKEGAVMMGQQVARVVESKNS AFPAGSIVLAQSGWTTHFISDGKGLEKLLTEWPDKLPLSL ALGTIGMPGLTAYFGLLEVCGVKGGETVLVSAAAGAVGSV VGQIAKLKGCKVVGAAGSDEKIAYLKQIGFDAAFNYKTVN SLEEALKKASPDGYDCYFDNVGGEFLNTVLSQMKDFGKIA ICGAISVYNRMDQLPPGPSPESIIYKQLRIEGFIVYRWQG DVREKALRDLMKWVLEGKIQYHEHVTKGFENMPAAFIEML NGANLGKAVVTA Description (1)  leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase (E.C.1.3.1.48) Functional site 1) chain B residue 149 type ligand sequence A description BINDING SITE FOR RESIDUE CL B 1002 source : AC2 2) chain B residue 151 type ligand sequence A description BINDING SITE FOR RESIDUE CL B 1002 source : AC2 3) chain B residue 173 type ligand sequence A description BINDING SITE FOR RESIDUE CL B 1002 source : AC2 4) chain B residue 174 type ligand sequence G description BINDING SITE FOR RESIDUE CL B 1002 source : AC2 5) chain B residue 178 type ligand sequence K description BINDING SITE FOR RESIDUE CL B 1002 source : AC2 6) chain B residue 12 type ligand sequence H description BINDING SITE FOR RESIDUE CL B 1003 source : AC3 7) chain B residue 13 type ligand sequence F description BINDING SITE FOR RESIDUE CL B 1003 source : AC3 8) chain B residue 54 type ligand sequence S description BINDING SITE FOR RESIDUE CL B 1003 source : AC3 9) chain B residue 55 type ligand sequence K description BINDING SITE FOR RESIDUE CL B 1003 source : AC3 10) chain B residue 321 type ligand sequence N description BINDING SITE FOR RESIDUE CL B 1005 source : AC5 11) chain B residue 324 type ligand sequence K description BINDING SITE FOR RESIDUE CL B 1005 source : AC5 12) chain B residue 325 type ligand sequence A description BINDING SITE FOR RESIDUE CL B 1005 source : AC5 13) chain B residue 12 type ligand sequence H description BINDING SITE FOR RESIDUE CL B 1007 source : AC7 14) chain B residue 59 type ligand sequence E description BINDING SITE FOR RESIDUE CL B 1007 source : AC7 15) chain B residue 182 type BINDING ligand sequence L description NADP. source Swiss-Prot : SWS_FT_FI3 16) chain B residue 197 type BINDING ligand sequence N description NADP. source Swiss-Prot : SWS_FT_FI3 17) chain B residue 221 type BINDING ligand sequence E description NADP. source Swiss-Prot : SWS_FT_FI3 18) chain B residue 325 type BINDING ligand sequence A description NADP. source Swiss-Prot : SWS_FT_FI3 19) chain B residue 156-159 type NP_BIND ligand sequence SVVG description NADP. source Swiss-Prot : SWS_FT_FI4 20) chain B residue 243-249 type NP_BIND ligand sequence SVYNRMD description NADP. source Swiss-Prot : SWS_FT_FI4 21) chain B residue 274-276 type NP_BIND ligand sequence RWQ description NADP. source Swiss-Prot : SWS_FT_FI4

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