eF-site ID 1v11-AB PDB Code 1v11 Chain A, B click to enlarge Title CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE Classification OXIDOREDUCTASE Compound 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT Source (ODBB_HUMAN) Sequence A:  PQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINP SEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFY MTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPL ELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLAT QIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFN FAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGY GIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTY AIDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFE QAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYG EHYPLDHFDK B:  AHFTFQPEYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGE DVAFGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGI AVTGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFN CGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPR SPFQAKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPY NIPLSQAEVIQEGSDVTLVAWGTQVHVIREVASMAKEKLG VSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGG FASEISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYI PDKWKCYDALRKMINY Description Functional site 1) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 2) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE K A 501 source : AC1 3) chain A residue 163 type sequence P description BINDING SITE FOR RESIDUE K A 501 source : AC1 4) chain A residue 166 type sequence T description BINDING SITE FOR RESIDUE K A 501 source : AC1 5) chain A residue 167 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 6) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE MN A 503 source : AC2 7) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE MN A 503 source : AC2 8) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE MN A 503 source : AC2 9) chain A residue 113 type sequence Y description BINDING SITE FOR RESIDUE CL A 504 source : AC3 10) chain B residue 102 type sequence Y description BINDING SITE FOR RESIDUE CL A 504 source : AC3 11) chain B residue 146 type sequence H description BINDING SITE FOR RESIDUE CL A 504 source : AC3 12) chain A residue 392 type sequence H description BINDING SITE FOR RESIDUE CL A 505 source : AC4 13) chain B residue 330 type sequence W description BINDING SITE FOR RESIDUE CL A 505 source : AC4 14) chain B residue 55 type sequence R description BINDING SITE FOR RESIDUE CL A 506 source : AC5 15) chain A residue 354 type sequence R description BINDING SITE FOR RESIDUE CL A 507 source : AC6 16) chain B residue 128 type sequence G description BINDING SITE FOR RESIDUE K B 502 source : AC7 17) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE K B 502 source : AC7 18) chain B residue 131 type sequence T description BINDING SITE FOR RESIDUE K B 502 source : AC7 19) chain B residue 178 type sequence C description BINDING SITE FOR RESIDUE K B 502 source : AC7 20) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE K B 502 source : AC7 21) chain B residue 183 type sequence N description BINDING SITE FOR RESIDUE K B 502 source : AC7 22) chain A residue 114 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 23) chain A residue 162 type sequence S description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 24) chain A residue 164 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 25) chain A residue 192 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 26) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 27) chain A residue 194 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 28) chain A residue 195 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 29) chain A residue 198 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 30) chain A residue 220 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 31) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 32) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 33) chain A residue 225 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 34) chain A residue 226 type sequence I description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 35) chain B residue 46 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 36) chain B residue 74 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 37) chain B residue 76 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 38) chain B residue 98 type sequence Q description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 39) chain B residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC8 40) chain A residue 73 type sequence I description BINDING SITE FOR RESIDUE BEN A 701 source : AC9 41) chain A residue 76 type sequence E description BINDING SITE FOR RESIDUE BEN A 701 source : AC9 42) chain A residue 80 type sequence Q description BINDING SITE FOR RESIDUE BEN A 701 source : AC9 43) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE BEN A 701 source : AC9 44) chain A residue 346 type sequence M description BINDING SITE FOR RESIDUE BEN A 701 source : AC9 45) chain A residue 374 type sequence Q description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 46) chain B residue 260 type sequence W description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 47) chain B residue 284 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 48) chain B residue 290 type sequence E description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 49) chain B residue 294 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 50) chain B residue 309 type sequence R description BINDING SITE FOR RESIDUE GOL B 701 source : BC1 51) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE GOL B 702 source : BC2 52) chain B residue 88 type sequence V description BINDING SITE FOR RESIDUE GOL B 702 source : BC2 53) chain B residue 125 type sequence F description BINDING SITE FOR RESIDUE GOL B 702 source : BC2 54) chain B residue 309 type sequence R description BINDING SITE FOR RESIDUE GOL B 703 source : BC3 55) chain B residue 310 type sequence V description BINDING SITE FOR RESIDUE GOL B 703 source : BC3 56) chain B residue 311 type sequence C description BINDING SITE FOR RESIDUE GOL B 703 source : BC3 57) chain B residue 313 type sequence Y description BINDING SITE FOR RESIDUE GOL B 703 source : BC3 58) chain A residue 76 type catalytic sequence E description 280 source MCSA : MCSA1 59) chain A residue 162 type catalytic sequence S description 280 source MCSA : MCSA1 60) chain B residue 102 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 61) chain A residue 195 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 62) chain A residue 220 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 63) chain A residue 222 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 64) chain A residue 224 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 65) chain B residue 128 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 66) chain B residue 130 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 67) chain B residue 131 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 68) chain B residue 178 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 69) chain B residue 181 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 70) chain B residue 183 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 71) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 72) chain A residue 194 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 73) chain B residue 182 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q6P3A8 source Swiss-Prot : SWS_FT_FI2 74) chain B residue 191 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 75) chain A residue 335 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P50136 source Swiss-Prot : SWS_FT_FI6

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