eF-site ID 1uws-AB PDB Code 1uws Chain A, B click to enlarge Title Structure of beta-glycosidase from Sulfolobus solfataricus in complex with 2-deoxy-2-fluoro-glucose Classification HYDROLASE Compound BETA-GALACTOSIDASE Source Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (BGAM_SULSO) Sequence A:  MYSFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHDP ENMAAGLVSGDLPENGPGYWGNYKTFHDNAQKMGLKIARL NVEWSRIFPNPLPRPFDESKQDVTEVEINENELKRLDEYA NKDALNHYREIFKDLKSRGLYFILNMYHWPLPLWLHDPIR VRRGDFTGPSGWLSTRTVYEFARFSAYIAWKFDDLVDEYS TMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQA HARAYDGIKSVSKKPVGIIYANSSFQPLTDKDMEAVEMAE NDNRWWFFDAIIRGEITKIVRDDLKGRLDWIGVNYYTRTV VKRTEKGYVSLGGYGHGCERNSVSLAGLPTSDFGWEFFPE GLYDVLTKYWNRYHLYMYVTENGIADDADYQRPYYLVSHV YQVHRAINSGADVRGYLHWSLADNYEWASGFSMRFGLLKV DYNTKRLYWRPSALVYREIATNGAITDEIEHLNSVPPVKP LRH B:  MYSFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHDP ENMAAGLVSGDLPENGPGYWGNYKTFHDNAQKMGLKIARL NVEWSRIFPNPLPRPFDESKQDVTEVEINENELKRLDEYA NKDALNHYREIFKDLKSRGLYFILNMYHWPLPLWLHDPIR VRRGDFTGPSGWLSTRTVYEFARFSAYIAWKFDDLVDEYS TMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQA HARAYDGIKSVSKKPVGIIYANSSFQPLTDKDMEAVEMAE NDNRWWFFDAIIRGEITREKIVRDDLKGRLDWIGVNYYTR TVVKRTEKGYVSLGGYGHGCERNSVSLAGLPTSDFGWEFF PEGLYDVLTKYWNRYHLYMYVTENGIADDADYQRPYYLVS HVYQVHRAINSGADVRGYLHWSLADNYEWASGFSMRFGLL KVDYNTKRLYWRPSALVYREIATNGAITDEIEHLNSVPPV KPLRH Description Functional site 1) chain A residue 206 type ACT_SITE sequence E description Proton donor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 206 type ACT_SITE sequence E description Proton donor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 387 type ACT_SITE sequence E description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10055 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 387 type ACT_SITE sequence E description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10055 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 116 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 6) chain A residue 273 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 7) chain A residue 311 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 8) chain B residue 116 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 9) chain B residue 273 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 311 type MOD_RES sequence K description N6-methyllysine; partial => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 135 type MOD_RES sequence K description N6-methyllysine => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI5 12) chain A residue 332 type MOD_RES sequence K description N6-methyllysine => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI5 13) chain B residue 135 type MOD_RES sequence K description N6-methyllysine => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI5 14) chain B residue 332 type MOD_RES sequence K description N6-methyllysine => ECO:0000269|PubMed:14660666 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 76 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 16) chain A residue 102 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 17) chain A residue 124 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 18) chain A residue 138 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 19) chain B residue 76 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 20) chain B residue 102 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 21) chain B residue 124 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 22) chain B residue 138 type SITE sequence K description Not N6-methylated source Swiss-Prot : SWS_FT_FI3 23) chain A residue 383-391 type prosite sequence MYVTENGIA description GLYCOSYL_HYDROL_F1_1 Glycosyl hydrolases family 1 active site. MYVTENGIA source prosite : PS00572 24) chain A residue 8-22 type prosite sequence FRFGWSQAGFQSEMG description GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FrFGwSqAGFQsEmG source prosite : PS00653

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