eF-site ID 1uv5-A PDB Code 1uv5 Chain A click to enlarge Title GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME Classification TRANSFERASE Compound GLYCOGEN SYNTHASE KINASE-3 BETA Source null (GSKG3B_HUMAN) Sequence A:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQGKAFKNRELQIMRKLDHCNIVRLRY FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI ALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGR DTPALFNFTTQELSSNPPLATILIPPHAR Description Functional site 1) chain A residue 173 type sequence H description BINDING SITE FOR RESIDUE PO4 A1384 source : AC1 2) chain A residue 236 type sequence S description BINDING SITE FOR RESIDUE PO4 A1384 source : AC1 3) chain A residue 237 type sequence S description BINDING SITE FOR RESIDUE PO4 A1384 source : AC1 4) chain A residue 331 type sequence P description BINDING SITE FOR RESIDUE PO4 A1384 source : AC1 5) chain A residue 359 type sequence L description BINDING SITE FOR RESIDUE CL A1385 source : AC2 6) chain A residue 360 type sequence F description BINDING SITE FOR RESIDUE CL A1385 source : AC2 7) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE CO A1386 source : AC3 8) chain A residue 96 type sequence R description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 9) chain A residue 180 type sequence R description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 10) chain A residue 205 type sequence K description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 11) chain A residue 213 type sequence N description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 12) chain A residue 214 type sequence V description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 13) chain A residue 290 type sequence E description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 14) chain A residue 291 type sequence F description BINDING SITE FOR RESIDUE PO4 A1387 source : AC4 15) chain A residue 62 type sequence I description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 16) chain A residue 83 type sequence A description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 17) chain A residue 133 type sequence D description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 18) chain A residue 134 type sequence Y description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 19) chain A residue 135 type sequence V description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 20) chain A residue 136 type sequence P description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 21) chain A residue 141 type sequence R description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 22) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 23) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE BRW A1383 source : AC5 24) chain A residue 177-189 type prosite sequence ICHRDIKPQNLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL source prosite : PS00108 25) chain A residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 26) chain A residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI4 27) chain A residue 62-86 type prosite sequence IGNGSFGVVYQAKLCDSGELVAIKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK source prosite : PS00107 28) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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