eF-site ID 1umd-D PDB Code 1umd Chain D click to enlarge Title branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 with 4-methyl-2-oxopentanoate as an intermediate Classification OXIDOREDUCTASE Compound 2-oxo acid dehydrogenase alpha subunit Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (ODBB_THET8) Sequence D:  ALMTMVQALNRALDEEMAKDPRVVVLGEDVGKRGGVFLVT EGLLQKYGPDRVMDTPLSEAAIVGAALGMAAHGLRPVAEI QFADYIFPGFDQLVSQVAKLRYRSGGQFTAPLVVRMPSGG GVRGGHHHSQSPEAHFVHTAGLKVVAVSTPYDAKGLLKAA IRDEDPVVFLEPKRLYRSVKEEVPEEDYTLPIGKAALRRE GKDLTLICYGTVMPEVLQAAAELAKAGVSAEVLDLRTLMP WDYEAVMNSVAKTGRVVLVSDAPRHASFVSEVAATIAEDL LDMLLAPPIRVTGFDTPYPYAQDKLYLPTVTRILNAAKRA LDY Description Functional site 1) chain D residue 29 type sequence E description BINDING SITE FOR RESIDUE TPP A 1402 source : AC3 2) chain D residue 58 type sequence L description BINDING SITE FOR RESIDUE TPP A 1402 source : AC3 3) chain D residue 60 type sequence E description BINDING SITE FOR RESIDUE TPP A 1402 source : AC3 4) chain D residue 82 type sequence Q description BINDING SITE FOR RESIDUE TPP A 1402 source : AC3 5) chain D residue 86 type sequence Y description BINDING SITE FOR RESIDUE TPP A 1402 source : AC3 6) chain D residue 86 type sequence Y description BINDING SITE FOR RESIDUE COI A 1403 source : AC4 7) chain D residue 129 type sequence H description BINDING SITE FOR RESIDUE COI A 1403 source : AC4 8) chain D residue 129 type ACT_SITE sequence H description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 29 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15033367 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 82 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15033367 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 58 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI3 12) chain D residue 83 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI3 13) chain D residue 86 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 14) chain D residue 129 type BINDING sequence H description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI4

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