eF-site ID 1umd-C PDB Code 1umd Chain C click to enlarge Title branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 with 4-methyl-2-oxopentanoate as an intermediate Classification OXIDOREDUCTASE Compound 2-oxo acid dehydrogenase alpha subunit Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (ODBB_THET8) Sequence C:  HRFETFTEEPIRLIGEEGEWLGDFPLDLEGEKLRRLYRDM LAARMLDERYTILIRTGKTSFIAPAAGHEAAQVAIAHAIR PGFDWVFPYYRDHGLALALGIPLKELLGQMLATKADPNKG RQMPEHPGSKALNFFTVASPIASHVPPAAGAAISMKLLRT GQVAVCTFGDGATSEGDWYAGINFAAVQGAPAVFIAENNF YAISVDYRHQTHSPTIADKAHAFGIPGYLVDGMDVLASYY VVKEAVERARRGEGPSLVELRVYRYGPHSSADDDSRYRPK EEVAFWRKKDPIPRFRRFLEARGLWNEEWEEDVREEIRAE LERGLKEAEEAGPVPPEWMFEDVFAEKPWHLLRQEALLKE E Description Functional site 1) chain C residue 175 type sequence D description BINDING SITE FOR RESIDUE MG C 2401 source : AC2 2) chain C residue 204 type sequence N description BINDING SITE FOR RESIDUE MG C 2401 source : AC2 3) chain C residue 206 type sequence Y description BINDING SITE FOR RESIDUE MG C 2401 source : AC2 4) chain C residue 94 type sequence Y description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 5) chain C residue 95 type sequence Y description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 6) chain C residue 96 type sequence R description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 7) chain C residue 144 type sequence S description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 8) chain C residue 145 type sequence P description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 9) chain C residue 146 type sequence I description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 10) chain C residue 174 type sequence G description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 11) chain C residue 175 type sequence D description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 12) chain C residue 176 type sequence G description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 13) chain C residue 177 type sequence A description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 14) chain C residue 180 type sequence E description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 15) chain C residue 204 type sequence N description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 16) chain C residue 206 type sequence Y description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 17) chain C residue 207 type sequence A description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 18) chain C residue 208 type sequence I description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 19) chain C residue 273 type sequence H description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 20) chain C residue 66 type sequence F description BINDING SITE FOR RESIDUE COI C 2403 source : AC6 21) chain C residue 144 type sequence S description BINDING SITE FOR RESIDUE COI C 2403 source : AC6 22) chain C residue 66 type ACT_SITE sequence F description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 94 type ACT_SITE sequence Y description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 95 type ACT_SITE sequence Y description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 25) chain C residue 128 type ACT_SITE sequence M description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 144 type ACT_SITE sequence S description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 27) chain C residue 174 type ACT_SITE sequence G description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 28) chain C residue 175 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 29) chain C residue 204 type ACT_SITE sequence N description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 30) chain C residue 206 type ACT_SITE sequence Y description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 273 type ACT_SITE sequence H description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1

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