eF-site ID 1umd-B PDB Code 1umd Chain B click to enlarge Title branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 with 4-methyl-2-oxopentanoate as an intermediate Classification OXIDOREDUCTASE Compound 2-oxo acid dehydrogenase alpha subunit Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (ODBB_THET8) Sequence B:  ALMTMVQALNRALDEEMAKDPRVVVLGEDVGKRGGVFLVT EGLLQKYGPDRVMDTPLSEAAIVGAALGMAAHGLRPVAEI QFADYIFPGFDQLVSQVAKLRYRSGGQFTAPLVVRMPSGG GVRGGHHHSQSPEAHFVHTAGLKVVAVSTPYDAKGLLKAA IRDEDPVVFLEPKRLYRSVKEEVPEEDYTLPIGKAALRRE GKDLTLICYGTVMPEVLQAAAELAKAGVSAEVLDLRTLMP WDYEAVMNSVAKTGRVVLVSDAPRHASFVSEVAATIAEDL LDMLLAPPIRVTGFDTPYPYAQDKLYLPTVTRILNAAKRA LDY Description Functional site 1) chain B residue 29 type sequence E description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 2) chain B residue 58 type sequence L description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 3) chain B residue 60 type sequence E description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 4) chain B residue 82 type sequence Q description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 5) chain B residue 86 type sequence Y description BINDING SITE FOR RESIDUE TPP C 2402 source : AC5 6) chain B residue 86 type sequence Y description BINDING SITE FOR RESIDUE COI C 2403 source : AC6 7) chain B residue 129 type sequence H description BINDING SITE FOR RESIDUE COI C 2403 source : AC6 8) chain B residue 129 type ACT_SITE sequence H description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 29 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15033367 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 82 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15033367 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 58 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI3 12) chain B residue 83 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI3 13) chain B residue 86 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 14) chain B residue 129 type BINDING sequence H description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI4

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