eF-site ID 1umd-A
PDB Code 1umd
Chain A

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Title branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 with 4-methyl-2-oxopentanoate as an intermediate
Classification OXIDOREDUCTASE
Compound 2-oxo acid dehydrogenase alpha subunit
Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (ODBB_THET8)
Sequence A:  HRFETFTEEPIRLIGEEGEWLGDFPLDLEGEKLRRLYRDM
LAARMLDERYTILIRTGKTSFIAPAAGHEAAQVAIAHAIR
PGFDWVFPYYRDHGLALALGIPLKELLGQMLATKADPNKG
RQMPEHPGSKALNFFTVASPIASHVPPAAGAAISMKLLRT
GQVAVCTFGDGATSEGDWYAGINFAAVQGAPAVFIAENNF
YAISVDYRHQTHSPTIADKAHAFGIPGYLVDGMDVLASYY
VVKEAVERARRGEGPSLVELRVYRYGPHSSADDDSRYRPK
EEVAFWRKKDPIPRFRRFLEARGLWNEEWEEDVREEIRAE
LERGLKEAEEAGPVPPEWMFEDVFAEKPWHLLRQEALLKE
EL
Description


Functional site

1) chain A
residue 175
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1401
source : AC1

2) chain A
residue 204
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1401
source : AC1

3) chain A
residue 206
type
sequence Y
description BINDING SITE FOR RESIDUE MG A 1401
source : AC1

4) chain A
residue 94
type
sequence Y
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

5) chain A
residue 95
type
sequence Y
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

6) chain A
residue 96
type
sequence R
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

7) chain A
residue 144
type
sequence S
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

8) chain A
residue 145
type
sequence P
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

9) chain A
residue 146
type
sequence I
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

10) chain A
residue 174
type
sequence G
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

11) chain A
residue 175
type
sequence D
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

12) chain A
residue 176
type
sequence G
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

13) chain A
residue 177
type
sequence A
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

14) chain A
residue 180
type
sequence E
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

15) chain A
residue 204
type
sequence N
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

16) chain A
residue 206
type
sequence Y
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

17) chain A
residue 207
type
sequence A
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

18) chain A
residue 208
type
sequence I
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

19) chain A
residue 273
type
sequence H
description BINDING SITE FOR RESIDUE TPP A 1402
source : AC3

20) chain A
residue 66
type
sequence F
description BINDING SITE FOR RESIDUE COI A 1403
source : AC4

21) chain A
residue 144
type
sequence S
description BINDING SITE FOR RESIDUE COI A 1403
source : AC4

22) chain A
residue 364-367
type prosite
sequence KEEL
description ER_TARGET Endoplasmic reticulum targeting sequence. KEEL
source prosite : PS00014

23) chain A
residue 273
type ACT_SITE
sequence H
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 95
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

25) chain A
residue 128
type ACT_SITE
sequence M
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

26) chain A
residue 144
type ACT_SITE
sequence S
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

27) chain A
residue 174
type ACT_SITE
sequence G
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 175
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 204
type ACT_SITE
sequence N
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 206
type ACT_SITE
sequence Y
description Proton acceptor => ECO:0000305
source Swiss-Prot : SWS_FT_FI1


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