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eF-site ID
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1uma-H |
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PDB Code
|
1uma |
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Chain
|
H |
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click to enlarge
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Title
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ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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ALPHA-THROMBIN |
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Source
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ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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H: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETWGQPSVLQVVNLP
IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL
KKWIQKVIDQFGE
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Description
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(1) |
ALPHA-THROMBIN, HIRUDIN I, SULFO GROUP, N,N-DIMETHYLCARBAMOYL-ALPHA-AZALYSINE
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Functional site
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1)
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chain |
H |
| residue |
53-58 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
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| source |
prosite : PS00134
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2)
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chain |
H |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
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| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
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3)
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chain |
H |
| residue |
102 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938
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| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
H |
| residue |
195 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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5)
|
chain |
H |
| residue |
60 |
| type |
CARBOHYD |
| sequence |
L
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
|
| source |
Swiss-Prot : SWS_FT_FI2
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