|
|
eF-site ID
|
1uk2-AB |
|
PDB Code
|
1uk2 |
|
Chain
|
A, B |
|
click to enlarge
|
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Title
|
Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) At pH8.0 |
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Classification
|
HYDROLASE |
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Compound
|
3C-LIKE PROTEINASE |
|
Source
|
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (R1AB_CVHSA) |
|
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Sequence
|
A: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
ILGSTILEDEFTPFDVVRQCSG
|
| B: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
ILGSTILEDEFTPFDVVRQCSG
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
41 |
| type |
catalytic |
| sequence |
H
|
| description |
830
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
A |
| residue |
143 |
| type |
catalytic |
| sequence |
G
|
| description |
830
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
A |
| residue |
145 |
| type |
catalytic |
| sequence |
C
|
| description |
830
|
| source |
MCSA : MCSA1
|
|
|
4)
|
chain |
B |
| residue |
41 |
| type |
catalytic |
| sequence |
H
|
| description |
830
|
| source |
MCSA : MCSA2
|
|
|
5)
|
chain |
B |
| residue |
143 |
| type |
catalytic |
| sequence |
G
|
| description |
830
|
| source |
MCSA : MCSA2
|
|
|
6)
|
chain |
B |
| residue |
145 |
| type |
catalytic |
| sequence |
C
|
| description |
830
|
| source |
MCSA : MCSA2
|
|
|
7)
|
chain |
A |
| residue |
41 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
145 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
B |
| residue |
41 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
B |
| residue |
145 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|