|
eF-site ID
|
1uk2-AB |
PDB Code
|
1uk2 |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) At pH8.0 |
Classification
|
HYDROLASE |
Compound
|
3C-LIKE PROTEINASE |
Source
|
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (R1AB_CVHSA) |
|
Sequence
|
A: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
ILGSTILEDEFTPFDVVRQCSG
|
B: |
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
ILGSTILEDEFTPFDVVRQCSG
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
41 |
type |
catalytic |
sequence |
H
|
description |
830
|
source |
MCSA : MCSA1
|
|
2)
|
chain |
A |
residue |
143 |
type |
catalytic |
sequence |
G
|
description |
830
|
source |
MCSA : MCSA1
|
|
3)
|
chain |
A |
residue |
145 |
type |
catalytic |
sequence |
C
|
description |
830
|
source |
MCSA : MCSA1
|
|
4)
|
chain |
B |
residue |
41 |
type |
catalytic |
sequence |
H
|
description |
830
|
source |
MCSA : MCSA2
|
|
5)
|
chain |
B |
residue |
143 |
type |
catalytic |
sequence |
G
|
description |
830
|
source |
MCSA : MCSA2
|
|
6)
|
chain |
B |
residue |
145 |
type |
catalytic |
sequence |
C
|
description |
830
|
source |
MCSA : MCSA2
|
|
7)
|
chain |
A |
residue |
41 |
type |
ACT_SITE |
sequence |
H
|
description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
8)
|
chain |
A |
residue |
145 |
type |
ACT_SITE |
sequence |
C
|
description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
9)
|
chain |
B |
residue |
41 |
type |
ACT_SITE |
sequence |
H
|
description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
10)
|
chain |
B |
residue |
145 |
type |
ACT_SITE |
sequence |
C
|
description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|