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eF-site ID
|
1uj3-ABC |
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PDB Code
|
1uj3 |
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Chain
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A, B, C |
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click to enlarge
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Title
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Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor |
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Classification
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IMMUNE SYSTEM/BLOOD CLOTTING |
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Compound
|
IgG Fab light chain |
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Source
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(1UJ3) |
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Sequence
|
A: |
DIQMTQSPSSLSASVGDRVTITCKASQDIKSFLSWYQQKP
EKAPKSLIYYATSLADGVPSRFSGSGSGTDYTLTISSLQP
EDFATYYCLQHGESPYTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGEC
|
| B: |
QVQLLESGAVLARPGTSVKISCKASGFNIKDYYMHWVKQR
PGQGLEWIGGNDPANGHSMYDPKFQGRVTITADTSTSTVF
MELSSLRSEDTAVYYCARDSGYAMDYWGQGTLVTVSSAST
KGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTC
NVDHKPSNTKVDKRVES
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| C: |
TVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDW
KSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVES
TGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNV
TVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGK
KTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDS
PVECM
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Description
|
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Functional site
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|
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1)
|
chain |
C |
| residue |
724 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
C |
| residue |
737 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
C |
| residue |
645-662 |
| type |
prosite |
| sequence |
WKSKCFYTTDTECDLTDE
|
| description |
TISSUE_FACTOR Tissue factor signature. WKsKCfyTtDTECDLTDE
|
| source |
prosite : PS00621
|
|
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4)
|
chain |
B |
| residue |
498-504 |
| type |
prosite |
| sequence |
YTCNVDH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH
|
| source |
prosite : PS00290
|
|
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5)
|
chain |
A |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH
|
| source |
prosite : PS00290
|
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