eF-site ID 1uj1-AB PDB Code 1uj1 Chain A, B click to enlarge Title Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) Classification HYDROLASE Compound 3C-like proteinase Source null (R1AB_CVHSA) Sequence A:  FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV ICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSM QNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSP SGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYM HHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITL NVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL TQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTIL GSTILEDEFTPFDVVRQCSGV B:  SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT ILGSTILEDEFTPFDVVRQCSG Description Functional site 1) chain B residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 145 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 145 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 145 type catalytic sequence C description 830 source MCSA : MCSA1 6) chain A residue 41 type catalytic sequence H description 830 source MCSA : MCSA1 7) chain A residue 143 type catalytic sequence G description 830 source MCSA : MCSA1 8) chain B residue 145 type catalytic sequence C description 830 source MCSA : MCSA2 9) chain B residue 41 type catalytic sequence H description 830 source MCSA : MCSA2 10) chain B residue 143 type catalytic sequence G description 830 source MCSA : MCSA2

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