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eF-site ID
|
1ui7-B |
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PDB Code
|
1ui7 |
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Chain
|
B |
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click to enlarge
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Title
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Site-directed mutagenesis of His433 involved in binding of copper ion in Arthrobacter globiformis amine oxidase |
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Classification
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OXIDOREDUCTASE |
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Compound
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Phenylethylamine oxidase |
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Source
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null (PAOX_ARTGO) |
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Sequence
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B: |
ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPA
RGAGSEAEDRRFRVFIHDVSGARPQEVTVSVTNGTVISAV
ELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLD
VSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAW
AHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE
LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVG
FDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPS
PIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVI
SDAFGNPREIRNGICMHEEDWGILAKHSDLWSGINYTRRN
RRMVISFFTTIGNYDYGFYWYLYLDGTIEFEAKATGVVFT
SAFPEGGSDNISQLAPGLGAPFHQAIFSARLDMAIDGFTN
RVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREAD
ARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGS
SIARRAAFATKDLWVTRYADDERYPTGDFVNQHSGGAGLP
SYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVG
FKLRPEGFFDRSPVLDVPAN
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
382 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE CU B 1003
|
| source |
: AC3
|
|
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2)
|
chain |
B |
| residue |
431 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CU B 1003
|
| source |
: AC3
|
|
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3)
|
chain |
B |
| residue |
592 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CU B 1003
|
| source |
: AC3
|
|
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4)
|
chain |
B |
| residue |
161 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CU B 1004
|
| source |
: AC4
|
|
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5)
|
chain |
B |
| residue |
165 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CU B 1004
|
| source |
: AC4
|
|
|
6)
|
chain |
B |
| residue |
170 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CU B 1004
|
| source |
: AC4
|
|
|
7)
|
chain |
B |
| residue |
201 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE CU B 1004
|
| source |
: AC4
|
|
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8)
|
chain |
B |
| residue |
298 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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9)
|
chain |
B |
| residue |
382 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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10)
|
chain |
B |
| residue |
296 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000250|UniProtKB:P12807
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
B |
| residue |
379 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000250|UniProtKB:P46883
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
B |
| residue |
382 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
2',4',5'-topaquinone => ECO:0000269|PubMed:9405045
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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13)
|
chain |
B |
| residue |
431 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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14)
|
chain |
B |
| residue |
433 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
|
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15)
|
chain |
B |
| residue |
592 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3
|
| source |
Swiss-Prot : SWS_FT_FI5
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