|
|
eF-site ID
|
1u7f-C |
|
PDB Code
|
1u7f |
|
Chain
|
C |
|
click to enlarge
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Title
|
Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex |
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Classification
|
SIGNALING PROTEIN |
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Compound
|
Mothers against decapentaplegic homolog 3 |
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Source
|
Homo sapiens (Human) (SMAD4_HUMAN) |
|
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Sequence
|
C: |
AFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF
CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLS
DSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFA
ALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSXVX
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
422 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
2)
|
chain |
C |
| residue |
423 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
C |
| residue |
418 |
| type |
CROSSLNK |
| sequence |
S
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
C |
| residue |
378 |
| type |
SITE |
| sequence |
K
|
| description |
Necessary for heterotrimerization
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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|
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