|
|
eF-site ID
|
1u7f-B |
|
PDB Code
|
1u7f |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex |
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Classification
|
SIGNALING PROTEIN |
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Compound
|
Mothers against decapentaplegic homolog 3 |
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Source
|
Homo sapiens (Human) (SMAD4_HUMAN) |
|
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Sequence
|
B: |
ISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGY
VDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKG
EGDVWVRCLSDHAVFVQSYYLDREDAVHKIYPSAYIKVFD
LRQCHRQMQQQAATAQIGVDDLRRLCILRMSFVKGWGPDY
PRQSIKETPCWIEIHLHRALQLLDEVLHTMPIA
|
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Description
|
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Functional site
|
|
|
1)
|
chain |
B |
| residue |
428 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
B |
| residue |
507 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
519 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
B |
| residue |
515 |
| type |
SITE |
| sequence |
R
|
| description |
Necessary for heterotrimerization
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|