eF-site ID 1u7f-ABC PDB Code 1u7f Chain A, B, C click to enlarge Title Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex Classification SIGNALING PROTEIN Compound Mothers against decapentaplegic homolog 3 Source null (SMAD4_HUMAN) Sequence A:  EPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAEC LSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQE FAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQ TVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSXVX B:  ISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGY VDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKG EGDVWVRCLSDHAVFVQSYYLDREDAVHKIYPSAYIKVFD LRQCHRQMQQQAATAQIGVDDLRRLCILRMSFVKGWGPDY PRQSIKETPCWIEIHLHRALQLLDEVLHTMPIA C:  AFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLS DSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFA ALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSXVX Description Functional site 1) chain A residue 422 type MOD_RES sequence S description Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439 source Swiss-Prot : SWS_FT_FI4 2) chain A residue 423 type MOD_RES sequence X description Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439 source Swiss-Prot : SWS_FT_FI4 3) chain C residue 422 type MOD_RES sequence S description Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439 source Swiss-Prot : SWS_FT_FI4 4) chain C residue 423 type MOD_RES sequence X description Phosphoserine; by TGFBR1 => ECO:0000250|UniProtKB:Q8BUN5, ECO:0000255|PROSITE-ProRule:PRU00439 source Swiss-Prot : SWS_FT_FI4 5) chain B residue 507 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 428 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 418 type CROSSLNK sequence S description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894 source Swiss-Prot : SWS_FT_FI3 8) chain B residue 519 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19135894 source Swiss-Prot : SWS_FT_FI3 9) chain C residue 378 type SITE sequence K description Necessary for heterotrimerization source Swiss-Prot : SWS_FT_FI1 10) chain B residue 515 type SITE sequence R description Necessary for heterotrimerization source Swiss-Prot : SWS_FT_FI1

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