|
|
eF-site ID
|
1u46-AB |
|
PDB Code
|
1u46 |
|
Chain
|
A, B |
|
click to enlarge
|
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Title
|
Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 |
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Classification
|
TRANSFERASE |
|
Compound
|
Activated CDC42 kinase 1 |
|
Source
|
Homo sapiens (Human) (ACK1_HUMAN) |
|
|
Sequence
|
A: |
LTCLIGEKDLRLLEKLGGVVRRGEWDAPSGKTVSVAVKCP
EAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELA
PLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRF
IHRDLAARNLLLATRDLVKIGDFGLMRALPQDDHYVMVPF
AWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL
NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPED
RPTFVALRDFLLEAQ
|
| B: |
LTCLIGEKDLRLLEKLGGVVRRGEWDAPSGKTVSVAVKCM
DDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLG
SLLDRLRKHQGLLGTLSRYAVQVAEGMGYLESKRFIHRDL
AARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVP
FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIG
LNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPE
DRPTFVALRDFLLEAQP
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
251 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE CL B 1
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
286 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE CL B 1
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
287 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE CL B 1
|
| source |
: AC1
|
|
|
4)
|
chain |
B |
| residue |
290 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE CL B 1
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
252 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
252 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
132 |
| type |
BINDING |
| sequence |
L
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
158 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
B |
| residue |
132 |
| type |
BINDING |
| sequence |
L
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
B |
| residue |
158 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
A |
| residue |
284 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by SRC and autocatalysis => ECO:0000269|PubMed:15308621, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20623637, ECO:0000269|PubMed:20979614, ECO:0000269|PubMed:21169560, ECO:0000269|PubMed:21309750, ECO:0007744|PubMed:19369195
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
B |
| residue |
284 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by SRC and autocatalysis => ECO:0000269|PubMed:15308621, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20623637, ECO:0000269|PubMed:20979614, ECO:0000269|PubMed:21169560, ECO:0000269|PubMed:21309750, ECO:0007744|PubMed:19369195
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
13)
|
chain |
A |
| residue |
132-158 |
| type |
prosite |
| sequence |
LGGVVRRGEWDAPSGKTVSVAVK
|
| description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGVVRrGewdapsgktvs.......VAVK
|
| source |
prosite : PS00107
|
|
|
14)
|
chain |
A |
| residue |
248-260 |
| type |
prosite |
| sequence |
FIHRDLAARNLLL
|
| description |
PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNLLL
|
| source |
prosite : PS00109
|
|
|
|