eF-site ID 1u1d-ABCDEF PDB Code 1u1d Chain A, B, C, D, E, F click to enlarge Title Structure of e. coli uridine phosphorylase complexed to 5-(phenylthio)acyclouridine (ptau) Classification TRANSFERASE Compound Uridine phosphorylase Source (UDP_ECOLI) Sequence A:  MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDK PVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEE LAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGAS LHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSD TFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESA TLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESH AVKIVVEAARRLL B:  KSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPV KLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELA QLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLH FAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTF YPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATL LTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAV KIVVEAARRLL C:  SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVK LASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQ LGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHF APLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFY PGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLL TMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVK IVVEAARRLL D:  SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVK LASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQ LGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHF APLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFY PGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLL TMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVK IVVEAARRLL E:  KSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPV KLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELA QLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLH FAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTF YPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATL LTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAV KIVVEAARRLL F:  SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVK LASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQ LGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHF APLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFY PGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLL TMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVK IVVEAARRLL Description Functional site 1) chain A residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 2) chain A residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 3) chain A residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 4) chain A residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 5) chain A residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 6) chain A residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 7) chain A residue 198 type sequence E description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 8) chain B residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 A 3401 source : AC1 9) chain A residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 10) chain B residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 11) chain B residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 12) chain B residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 13) chain B residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 14) chain B residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 15) chain B residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 16) chain B residue 198 type sequence E description BINDING SITE FOR RESIDUE PO4 B 4401 source : AC2 17) chain C residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 18) chain C residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 19) chain C residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 20) chain C residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 21) chain C residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 22) chain C residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 23) chain C residue 198 type sequence E description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 24) chain D residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 C 5401 source : AC3 25) chain C residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 26) chain D residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 27) chain D residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 28) chain D residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 29) chain D residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 30) chain D residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 31) chain D residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 D 6401 source : AC4 32) chain E residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 33) chain E residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 34) chain E residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 35) chain E residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 36) chain E residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 37) chain E residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 38) chain E residue 198 type sequence E description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 39) chain F residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 E 7401 source : AC5 40) chain E residue 48 type sequence R description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 41) chain F residue 26 type sequence G description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 42) chain F residue 30 type sequence R description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 43) chain F residue 91 type sequence R description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 44) chain F residue 92 type sequence I description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 45) chain F residue 93 type sequence G description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 46) chain F residue 94 type sequence T description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 47) chain F residue 198 type sequence E description BINDING SITE FOR RESIDUE PO4 F 8401 source : AC6 48) chain A residue 49 type sequence E description BINDING SITE FOR RESIDUE K A 1001 source : AC7 49) chain A residue 69 type sequence I description BINDING SITE FOR RESIDUE K A 1001 source : AC7 50) chain A residue 73 type sequence S description BINDING SITE FOR RESIDUE K A 1001 source : AC7 51) chain B residue 49 type sequence E description BINDING SITE FOR RESIDUE K A 1001 source : AC7 52) chain B residue 69 type sequence I description BINDING SITE FOR RESIDUE K A 1001 source : AC7 53) chain B residue 73 type sequence S description BINDING SITE FOR RESIDUE K A 1001 source : AC7 54) chain C residue 49 type sequence E description BINDING SITE FOR RESIDUE K C 1002 source : AC8 55) chain C residue 69 type sequence I description BINDING SITE FOR RESIDUE K C 1002 source : AC8 56) chain C residue 73 type sequence S description BINDING SITE FOR RESIDUE K C 1002 source : AC8 57) chain D residue 49 type sequence E description BINDING SITE FOR RESIDUE K C 1002 source : AC8 58) chain D residue 69 type sequence I description BINDING SITE FOR RESIDUE K C 1002 source : AC8 59) chain D residue 73 type sequence S description BINDING SITE FOR RESIDUE K C 1002 source : AC8 60) chain E residue 49 type sequence E description BINDING SITE FOR RESIDUE K E 1003 source : AC9 61) chain E residue 69 type sequence I description BINDING SITE FOR RESIDUE K E 1003 source : AC9 62) chain E residue 73 type sequence S description BINDING SITE FOR RESIDUE K E 1003 source : AC9 63) chain F residue 49 type sequence E description BINDING SITE FOR RESIDUE K E 1003 source : AC9 64) chain F residue 69 type sequence I description BINDING SITE FOR RESIDUE K E 1003 source : AC9 65) chain F residue 73 type sequence S description BINDING SITE FOR RESIDUE K E 1003 source : AC9 66) chain A residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 67) chain A residue 95 type sequence T description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 68) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 69) chain A residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 70) chain A residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 71) chain A residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 72) chain A residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 73) chain A residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 74) chain A residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 75) chain A residue 220 type sequence I description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 76) chain A residue 227 type sequence E description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 77) chain B residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 78) chain B residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 A 3400 source : BC1 79) chain A residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 80) chain A residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 81) chain B residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 82) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 83) chain B residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 84) chain B residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 85) chain B residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 86) chain B residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 87) chain B residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 88) chain B residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 89) chain B residue 220 type sequence I description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 90) chain B residue 227 type sequence E description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 91) chain B residue 229 type sequence P description BINDING SITE FOR RESIDUE 181 B 4400 source : BC2 92) chain C residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 93) chain C residue 95 type sequence T description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 94) chain C residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 95) chain C residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 96) chain C residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 97) chain C residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 98) chain C residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 99) chain C residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 100) chain C residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 101) chain C residue 220 type sequence I description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 102) chain D residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 103) chain D residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 C 5400 source : BC3 104) chain C residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 105) chain C residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 106) chain D residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 107) chain D residue 95 type sequence T description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 108) chain D residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 109) chain D residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 110) chain D residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 111) chain D residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 112) chain D residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 113) chain D residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 114) chain D residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 115) chain D residue 220 type sequence I description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 116) chain D residue 227 type sequence E description BINDING SITE FOR RESIDUE 181 D 6400 source : BC4 117) chain E residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 118) chain E residue 95 type sequence T description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 119) chain E residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 120) chain E residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 121) chain E residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 122) chain E residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 123) chain E residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 124) chain E residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 125) chain E residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 126) chain F residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 127) chain F residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 E 7400 source : BC5 128) chain E residue 7 type sequence F description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 129) chain E residue 8 type sequence H description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 130) chain F residue 94 type sequence T description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 131) chain F residue 95 type sequence T description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 132) chain F residue 96 type sequence G description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 133) chain F residue 162 type sequence F description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 134) chain F residue 166 type sequence Q description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 135) chain F residue 168 type sequence R description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 136) chain F residue 195 type sequence Y description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 137) chain F residue 196 type sequence E description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 138) chain F residue 197 type sequence M description BINDING SITE FOR RESIDUE 181 F 8400 source : BC6 139) chain A residue 9 type catalytic sequence L description 787 source MCSA : MCSA1 140) chain A residue 81 type catalytic sequence L description 787 source MCSA : MCSA1 141) chain A residue 169 type catalytic sequence Y description 787 source MCSA : MCSA1 142) chain A residue 224 type catalytic sequence T description 787 source MCSA : MCSA1 143) chain B residue 9 type catalytic sequence L description 787 source MCSA : MCSA2 144) chain B residue 81 type catalytic sequence L description 787 source MCSA : MCSA2 145) chain B residue 169 type catalytic sequence Y description 787 source MCSA : MCSA2 146) chain B residue 224 type catalytic sequence T description 787 source MCSA : MCSA2 147) chain C residue 9 type catalytic sequence L description 787 source MCSA : MCSA3 148) chain C residue 81 type catalytic sequence L description 787 source MCSA : MCSA3 149) chain C residue 169 type catalytic sequence Y description 787 source MCSA : MCSA3 150) chain C residue 224 type catalytic sequence T description 787 source MCSA : MCSA3 151) chain D residue 9 type catalytic sequence L description 787 source MCSA : MCSA4 152) chain D residue 81 type catalytic sequence L description 787 source MCSA : MCSA4 153) chain D residue 169 type catalytic sequence Y description 787 source MCSA : MCSA4 154) chain D residue 224 type catalytic sequence T description 787 source MCSA : MCSA4 155) chain E residue 9 type catalytic sequence L description 787 source MCSA : MCSA5 156) chain E residue 81 type catalytic sequence L description 787 source MCSA : MCSA5 157) chain E residue 169 type catalytic sequence Y description 787 source MCSA : MCSA5 158) chain E residue 224 type catalytic sequence T description 787 source MCSA : MCSA5 159) chain F residue 9 type catalytic sequence L description 787 source MCSA : MCSA6 160) chain F residue 81 type catalytic sequence L description 787 source MCSA : MCSA6 161) chain F residue 169 type catalytic sequence Y description 787 source MCSA : MCSA6 162) chain F residue 224 type catalytic sequence T description 787 source MCSA : MCSA6 163) chain A residue 66-81 type prosite sequence STGIGGPSTSIAVEEL description PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL source prosite : PS01232

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