eF-site/Summary 1u04-A

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Title	Crystal structure of full length Argonaute from Pyrococcus furiosus
Classification	HYDROLASE/GENE REGULATION
Compound	hypothetical protein PF0537
Source	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (Q8U3D2_PYRFU)

Sequence	A:	SXKAIVVINLVKINKKIIPDKIYVYRLYSIYRLAYENVGI VIDPENLIIATTKELEYEGEFIPEGEISFSELRNDYQSKL VLRLLKENGIGEYELSKLLRKFRKPKTFGDYKVIPSVEXS VIKHDEDFYLVIHIIHQIQSXKTLWELVNKDPKELEEFLX THKENLXLKDIASPLKTVYKPCFEEYTKKPKLDHNQEIVK YWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFAS KNYKIYLLPQLVVPTYNAEQLAKEILEYTKLXPEERKELL ENILAEVDSDIIDKSLSEIEVEKIAQELENKIRVRDDKGN SVPISQLLWTNYSRKYPVILPYEVPEKFRKIREIPXFIIL DSGLLADIQNFATNEFRELVKSXYYEKVITEDLNSDKGII EVVEQVSSFXKGKELGLAFIAARNKLSSEKFEEIKRRLFN LNVISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSK LGVKYYVLDYRFNYDYIIGIDVAPXKRSEGYIGGSAVXFD SQGYIRKIVPIKIGEQRGESVDXNEFFKEXVDKFKEFNIK LDNKKILLLRDGRITNNEEEGLKYISEXFDIEVVTXDVIK NHPVRAFANXKXYFNLGGAIYLIPHKLKQAKGTPIPIKLA KKRIIKNGKVEKQSITRQDVLDIFILTRLNYGSISADXRL PAPVHYAHKFANAIRNEWKIKEEFLAEGFLYFV

Description

Functional site


1)	chain	A
	residue	558
	type	ACT_SITE
	sequence	D
	description	ACT_SITE => ECO:0000305\|PubMed:15284453, ECO:0000305\|PubMed:15800637
	source	Swiss-Prot : SWS_FT_FI1

2)	chain	A
	residue	628
	type	ACT_SITE
	sequence	D
	description	ACT_SITE => ECO:0000305\|PubMed:15284453, ECO:0000305\|PubMed:15800637
	source	Swiss-Prot : SWS_FT_FI1

3)	chain	A
	residue	596
	type	ACT_SITE
	sequence	E
	description	ACT_SITE => ECO:0000250\|UniProtKB:Q746M7
	source	Swiss-Prot : SWS_FT_FI2

4)	chain	A
	residue	745
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:15800637
	source	Swiss-Prot : SWS_FT_FI3

5)	chain	A
	residue	558
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:Q746M7
	source	Swiss-Prot : SWS_FT_FI4

6)	chain	A
	residue	770
	type	BINDING
	sequence	V
	description	BINDING => ECO:0000250\|UniProtKB:Q746M7
	source	Swiss-Prot : SWS_FT_FI4

7)	chain	A
	residue	628
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:Q746M7, ECO:0000269\|PubMed:15800637, ECO:0007744\|PDB:1Z25
	source	Swiss-Prot : SWS_FT_FI5

8)	chain	A
	residue	745
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:15800637, ECO:0007744\|PDB:1Z25
	source	Swiss-Prot : SWS_FT_FI6