eF-site ID 1tyl-ABCD PDB Code 1tyl Chain A, B, C, D click to enlarge Title THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE Classification HORMONE Compound INSULIN Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT C:  GIVEQCCTSICSLYQLENYCN D:  NQHLCGSHLVEALYLVCGERGFFYTPKT Description (1)  INSULIN (T3R3) (PH 6.4, 0.75 M NACL) COMPLEXED WITH TWO ZINC IONS AND TYLENOL (4'-HYDROXYACETANILIDE) Functional site 1) chain B residue 13 type sequence E description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 2) chain B residue 17 type sequence L description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 3) chain C residue 6 type sequence C description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 4) chain C residue 10 type sequence I description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 5) chain C residue 11 type sequence C description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 6) chain D residue 5 type sequence H description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 7) chain D residue 10 type sequence H description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 8) chain D residue 11 type sequence L description TYLENOL BINDING SITE, THE TYLENOL MOLECULE IS BOUND IN AN ELLIPTICAL CAVITY BETWEEN R STATE MONOMERS source : TYL 9) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 10) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 11) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 12) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC2 13) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC2 14) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC2 15) chain B residue 13 type sequence E description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 16) chain B residue 17 type sequence L description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 17) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 18) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 19) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 20) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 21) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 22) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 23) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 24) chain D residue 14 type sequence A description BINDING SITE FOR RESIDUE TYL C 100 source : AC4 25) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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