eF-site ID 1txx-A
PDB Code 1txx
Chain A

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Title ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN
Classification OXIDOREDUCTASE
Compound PROTEIN (THIOREDOXIN)
Source Escherichia coli (strain K12) (THIO_ECOLI)
Sequence A:  SDKIIHLTDDSFDTDVLKADGAILVDFWAEWCVWCKMIAP
ILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLL
FKNGEVAATKVGALSKGQLKEFLDANLA
Description


Functional site

1) chain A
residue 1
type
sequence S
description BINDING SITE FOR RESIDUE CU A 109
source : AC1

2) chain A
residue 2
type
sequence D
description BINDING SITE FOR RESIDUE CU A 109
source : AC1

3) chain A
residue 24-42
type prosite
sequence LVDFWAEWCVWCKMIAPIL
description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCVWCKmIapiL
source prosite : PS00194

4) chain A
residue 32
type ACT_SITE
sequence C
description Nucleophile
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 35
type ACT_SITE
sequence C
description Nucleophile
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 26
type SITE
sequence D
description Deprotonates C-terminal active site Cys
source Swiss-Prot : SWS_FT_FI2

7) chain A
residue 33
type SITE
sequence V
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

8) chain A
residue 34
type SITE
sequence W
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

9) chain A
residue 69
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:18723842
source Swiss-Prot : SWS_FT_FI4


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