eF-site ID 1twh-B PDB Code 1twh Chain B click to enlarge Title RNA polymerase II complexed with 2'dATP Classification TRANSCRIPTION Compound DNA-directed RNA polymerase II largest subunit Source ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence B:  FEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDY TLQDIICEDSTLIEISFGKIYVTKPMVNESDGVTHALYPQ EARLRNLTYSSGLFVDVKKRTYEKVFIGRLPIMLRSKNCY LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAG NIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYG REGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTA LGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGY MINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL FKKLTKDIFRYMQRTVELAINAKTITSGLKYALATGNWGA GVSQVLNRYTYSSTLSHLRRTNTPIAKPRQLHNTHWGLVC PAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGM EPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTL RRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDD ESLGHKELKVRKGHIAKLMATEYQDEYTWSSLLNEGLVEY IDAEEEESILIAMQPEDLEPDVDPAKRIRVSHHATTFTHC EIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVF LTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQ NAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMD QEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAP GVRVSGEDVIIGKTTSKRDASTPLRSTENGIVDQVLVTTN QDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRRE DMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAAL SGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHT GKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPGLRFGEM ERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIA KLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNIT PRLYTDRSRDF Description Functional site 1) chain B residue 837 type sequence D description BINDING SITE FOR RESIDUE MN A 3010 source : AC2 2) chain B residue 1163 type sequence C description BINDING SITE FOR RESIDUE ZN B 3007 source : AC9 3) chain B residue 1166 type sequence C description BINDING SITE FOR RESIDUE ZN B 3007 source : AC9 4) chain B residue 1182 type sequence C description BINDING SITE FOR RESIDUE ZN B 3007 source : AC9 5) chain B residue 1185 type sequence C description BINDING SITE FOR RESIDUE ZN B 3007 source : AC9 6) chain B residue 766 type sequence R description BINDING SITE FOR RESIDUE ATP A 3011 source : BC2 7) chain B residue 986 type sequence Q description BINDING SITE FOR RESIDUE ATP A 3011 source : BC2 8) chain B residue 987 type sequence K description BINDING SITE FOR RESIDUE ATP A 3011 source : BC2 9) chain B residue 1020 type sequence R description BINDING SITE FOR RESIDUE ATP A 3011 source : BC2 10) chain B residue 977-989 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166 11) chain B residue 837 type catalytic sequence D description 788 source MCSA : MCSA1 12) chain B residue 1185 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI2

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