eF-site ID 1tt5-B PDB Code 1tt5 Chain B click to enlarge Title Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Classification CELL CYCLE, LIGASE Compound amyloid protein-binding protein 1 Source Homo sapiens (Human) (UBCM_HUMAN) Sequence B:  MKLDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDT CKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNL NRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQ DFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGV LDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYP PQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVP LDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRI IPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVD GLYTYTFEAERKENCPACSQLPQNIQFLQEVLDYLTNSAS LQMKSPAITATNRTLYLQSVTSIEERTRPLSKGLVDGQEL AVADVTTPQTVLFK Description Functional site 1) chain B residue 199 type sequence C description BINDING SITE FOR RESIDUE ZN B 1014 source : AC1 2) chain B residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN B 1014 source : AC1 3) chain B residue 343 type sequence C description BINDING SITE FOR RESIDUE ZN B 1014 source : AC1 4) chain B residue 346 type sequence C description BINDING SITE FOR RESIDUE ZN B 1014 source : AC1 5) chain B residue 214-222 type prosite sequence PMCTIASMP description UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PMCTIAsMP source prosite : PS00865 6) chain B residue 216 type ACT_SITE sequence C description Glycyl thioester intermediate source Swiss-Prot : SWS_FT_FI1 7) chain B residue 79 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14690597 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 127 type BINDING sequence I description BINDING => ECO:0000269|PubMed:14690597 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 190 type SITE sequence R description Determines specificity for NEDD8 source Swiss-Prot : SWS_FT_FI3

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