eF-site ID 1tt5-D PDB Code 1tt5 Chain D click to enlarge Title Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Classification CELL CYCLE, LIGASE Compound amyloid protein-binding protein 1 Source null (UBCM_HUMAN) Sequence D:  WNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGA GGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRP KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYR QFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVP LIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMC TIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEH IQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTN AVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFE AERKENCPACSQLPQNIQLQEVLDYLTNSASLQMKSPAIT ATKNRTLYLQVTSIEERTRPLAVADVTTPQTVLFK Description Functional site 1) chain D residue 199 type sequence C description BINDING SITE FOR RESIDUE ZN D 1014 source : AC2 2) chain D residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN D 1014 source : AC2 3) chain D residue 343 type sequence C description BINDING SITE FOR RESIDUE ZN D 1014 source : AC2 4) chain D residue 346 type sequence C description BINDING SITE FOR RESIDUE ZN D 1014 source : AC2 5) chain D residue 216 type ACT_SITE sequence C description Glycyl thioester intermediate source Swiss-Prot : SWS_FT_FI1 6) chain D residue 190 type SITE sequence R description Determines specificity for NEDD8 source Swiss-Prot : SWS_FT_FI3 7) chain D residue 79 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14690597 source Swiss-Prot : SWS_FT_FI2 8) chain D residue 127 type BINDING sequence I description BINDING => ECO:0000269|PubMed:14690597 source Swiss-Prot : SWS_FT_FI2

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