eF-site ID 1tsi-AB PDB Code 1tsi Chain A, B click to enlarge Title STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP Classification ISOMERASE(INTRAMOLECULAR OXIDOREDUCTASE) Compound TRIOSEPHOSPHATE ISOMERASE Source Trypanosoma brucei brucei (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VRGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VRGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 2) chain A residue 13 type sequence K description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 3) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 4) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 5) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 6) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 7) chain A residue 211 type sequence G description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 8) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 9) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE 4PB A 600 source : AC1 10) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 11) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 12) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 13) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 14) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 15) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 16) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 17) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 18) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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