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eF-site ID
|
1tqc-ABC |
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PDB Code
|
1tqc |
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Chain
|
A, B, C |
|
click to enlarge
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Title
|
Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a) |
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Classification
|
UNKNOWN FUNCTION/IMMUNE SYSTEM |
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Compound
|
prion protein |
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Source
|
null (1TQC) |
|
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Sequence
|
A: |
GLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYY
RPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDI
KIMERVVEQMCITQYQRESQAY
|
| B: |
QIQLVQSGPELKKPGETVKISCKASGYTFTNYGMNLVKQA
PGKGFEWMGWINTFTGEPTYADDFKGRFVFSLDTSASTAY
LQINNLKNEDTATYFFTRGTDYWGQGTTLTVSSAKTTAPS
VYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLS
SGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHP
ASSTKVDKKIEP
|
| C: |
DVVMSQTPLTLSVTIGQPASISCKSSQSLLDSDGKTYLNW
LLQRPGQSPKRLIYLVSRLDSGVPDRFTGSGSGTDFTLKI
SRVEAEDLGIYFCWQGSHFPQTFGGGTKLEIKRADAAPTV
SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSER
QNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCE
ATHKTSTSPIVKSFNRNEC
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Description
|
(1) |
prion protein/VRQ14 Fab Heavy chain/VRQ14 Fab light chain
|
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
200 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:33600485
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
184 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:33600485
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
C |
| residue |
192-198 |
| type |
prosite |
| sequence |
YTCEATH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
|
| source |
prosite : PS00290
|
|
|
4)
|
chain |
A |
| residue |
203-221 |
| type |
prosite |
| sequence |
ETDIKIMERVVEQMCITQY
|
| description |
PRION_2 Prion protein signature 2. EtDiKIMeRVVeQMCitQY
|
| source |
prosite : PS00706
|
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