eF-site ID 1tpf-AB PDB Code 1tpf Chain A, B click to enlarge Title COMPARISON OF THE STRUCTURES AND THE CRYSTAL CONTACTS OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE IN FOUR DIFFERENT CRYSTAL FORMS Classification ISOMERASE(INTRAMOLECULAR OXIDOREDUCTASE) Compound TRIOSEPHOSPHATE ISOMERASE Source (TPIS_TRYBB) Sequence A:  MSKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCV VASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSL PILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASG FMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWA KVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGA DVAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKP EFVDIIKATQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE DMS A 251 source : AC1 2) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE DMS A 252 source : AC2 3) chain A residue 100 type sequence A description BINDING SITE FOR RESIDUE DMS A 252 source : AC2 4) chain A residue 101 type sequence Y description BINDING SITE FOR RESIDUE DMS A 252 source : AC2 5) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE DMS B 251 source : AC3 6) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE DMS B 251 source : AC3 7) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE DMS B 252 source : AC4 8) chain B residue 97 type sequence E description BINDING SITE FOR RESIDUE DMS B 252 source : AC4 9) chain B residue 100 type sequence A description BINDING SITE FOR RESIDUE DMS B 252 source : AC4 10) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 11) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 12) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 13) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 14) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 15) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 16) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 17) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 18) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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