eF-site ID 1tmj-A
PDB Code 1tmj
Chain A

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Title Crystal structure of E.coli apo-HPPK(W89A) at 1.45 Angstrom resolution
Classification TRANSFERASE
Compound 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Source Escherichia coli (strain K12) (HPPK_ECOLI)
Sequence A:  TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFY
RTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQ
GRVRKAERAGPRTLDLDIMLFGNEVINTERLTVPHYDMKN
RGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
Description


Functional site

1) chain A
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE MG A 161
source : AC1

2) chain A
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE MG A 161
source : AC1

3) chain A
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE MG A 162
source : AC2

4) chain A
residue 97
type
sequence D
description BINDING SITE FOR RESIDUE MG A 162
source : AC2

5) chain A
residue 114
type
sequence P
description BINDING SITE FOR RESIDUE CL A 163
source : AC3

6) chain A
residue 119
type
sequence K
description BINDING SITE FOR RESIDUE CL A 163
source : AC3

7) chain A
residue 137
type
sequence F
description BINDING SITE FOR RESIDUE CL A 163
source : AC3

8) chain A
residue 138
type
sequence P
description BINDING SITE FOR RESIDUE CL A 163
source : AC3

9) chain A
residue 139
type
sequence D
description BINDING SITE FOR RESIDUE CL A 163
source : AC3

10) chain A
residue 83
type catalytic
sequence V
description 151
source MCSA : MCSA1

11) chain A
residue 93
type catalytic
sequence T
description 151
source MCSA : MCSA1

12) chain A
residue 96
type catalytic
sequence L
description 151
source MCSA : MCSA1

13) chain A
residue 98
type catalytic
sequence I
description 151
source MCSA : MCSA1

14) chain A
residue 88-99
type prosite
sequence RAGPRTLDLDIM
description HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RaGPRtlDLDIM
source prosite : PS00794


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